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    Supt4b SPT4B, DSIF elongation factor subunit [ Mus musculus (house mouse) ]

    Gene ID: 100041294, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Supt4bprovided by MGI
    Official Full Name
    SPT4B, DSIF elongation factor subunitprovided by MGI
    Primary source
    MGI:MGI:1335090
    See related
    AllianceGenome:MGI:1335090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm3258; Supt4h2; Supt4h1b
    Summary
    Predicted to enable RNA polymerase II complex binding activity and protein heterodimerization activity. Predicted to be involved in RNA metabolic process; chromatin organization; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in brain; embryo; heart; and liver. Orthologous to human SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Supt4b in Genome Data Viewer
    Location:
    10 A4; 10 17.4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (31289722..31290431, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (31413726..31414435, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26213 Neighboring gene STARR-positive B cell enhancer ABC_E8329 Neighboring gene HD domain containing 2 Neighboring gene tumor protein D52-like 1 Neighboring gene STARR-seq mESC enhancer starr_26215 Neighboring gene predicted gene, 51764 Neighboring gene ring finger protein 217 Neighboring gene STARR-seq mESC enhancer starr_26216 Neighboring gene high mobility group box 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of murine Supt4h and a nearly identical expressed, processed gene: evidence of sequence conservation through gene conversion extending into the untranslated regions. Chiang PW, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776760, Free PMC Article
    2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DSIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DSIF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor SPT4-B
    Names
    DRB sensitivity-inducing factor small subunit 2
    DSIF small subunit 2
    suppressor of Ty 4 homolog 2
    suppressor of Ty 4B
    transcription elongation factor SPT4 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011509.2 → NP_035639.1  transcription elongation factor SPT4-B

      See identical proteins and their annotated locations for NP_035639.1

      Status: VALIDATED

      Source sequence(s)
      AC153729, EL607674
      UniProtKB/Swiss-Prot
      Q9Z199
      Conserved Domains (1) summary
      cd07973
      Location:11 → 108
      Spt4; Transcription elongation factor Spt4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      31289722..31290431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z199.1 GenPept UniProtKB/Swiss-Prot:Q9Z199

    Gene LinkOut

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