Cdo1 cysteine dioxygenase 1, cytosolic [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdo1provided by MGI
Official Full Name: cysteine dioxygenase 1, cytosolicprovided by MGI
Primary source: MGI:MGI:105925
See related: Ensembl:ENSMUSG00000033022 AllianceGenome:MGI:105925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdo; D18Ucla3; 1300002L19Rik
Summary: Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to act upstream of or within L-cysteine catabolic process to taurine. Located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 643.5), subcutaneous fat pad adult (RPKM 274.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 C; 18 24.75 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (46846260..46861569, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (46713193..46728502, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Title: Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Cdo1 promotes PPARgamma-mediated adipose tissue lipolysis in male mice.
Title: Cdo1 promotes PPARγ-mediated adipose tissue lipolysis in male mice.
findings suggest that epididymal CDO plays a key role in post-testicular sperm maturation, enabling sperm to osmoregulate as they transition from the male to the female reproductive tract
Title: Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility.
Presented here are the results of O2-dependent 2-mercaptoaniline reaction using two different thiol dioxygenase enzymes mouse CDO and 3-mercaptopropionic acid dioxygenase isolated from Azotobacter vinelandii. Benzothiazoles are produced by the condensation of 2-mercaptoaniline with aldehydes formed by an off-pathway oxidation of primary alcohols added to aqueous reactions to solubilize the substrate.
Title: Thiol dioxygenase turnover yields benzothiazole products from 2-mercaptoaniline and O(2)-dependent oxidation of primary alcohols.
Cdo is required for efficient cardiomyogenesis of pluripotent stem cells and an excellent target to improve the differentiation potential of stem cells for generation of transplantable cells to treat cardiomyopathies.
Title: A Shh coreceptor Cdo is required for efficient cardiomyogenesis of pluripotent stem cells.
our findings indicate Cdo1 suppresses osteogenic differentiation of BMSCs, through a potential mechanism which involves in Wnt signaling reduction concomitantly
Title: Cysteine Dioxygenase Type 1 Inhibits Osteogenesis by Regulating Wnt Signaling in Primary Mouse Bone Marrow Stromal Cells.
We investigated the ontogeny of Cdo1 mRNA expression in mouse fetal and placental tissues, which showed increasing levels from embryonic day 10.5 and was localised to the decidua and several fetal tissues including nasal cavities and brain.
Title: Placental and fetal cysteine dioxygenase gene expression in mouse gestation.
Cdo1 is required for adipogenesis.Cdo1 interacts with Ppar-gamma during adipogenesis.
Title: Cysteine dioxygenase type 1 promotes adipogenesis via interaction with peroxisome proliferator-activated receptor gamma.
In light of these results, the minimal substrate requirements for CDO catalysis and O-activation are discussed.
Title: Steady-state substrate specificity and O₂-coupling efficiency of mouse cysteine dioxygenase.
the timing of chemical steps in the CDO kinetic mechanism is investigated by pH/pD-dependent steady-state kinetics and solvent isotope effects on kcat, kcat/KM, and (O2/CSA) coupling
Title: Oxidative uncoupling in cysteine dioxygenase is gated by a proton-sensitive intermediate.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Cdo1 (e-PCR), detects polymorphism
- UniSTS:498340

Cdo1 (e-PCR), detects polymorphism
- UniSTS:498422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables cysteine dioxygenase activity	TAS Traceable Author Statement more info	PubMed
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-cysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-cysteine catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-cysteine catabolic process to taurine	TAS Traceable Author Statement more info	PubMed
involved_in lactation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to glucagon	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to organonitrogen compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within taurine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cysteine dioxygenase type 1

Names: CDO-I; cysteine dioxygenase type I

NP_149026.1

EC 1.13.11.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.