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    Fam168a family with sequence similarity 168, member A [ Mus musculus (house mouse) ]

    Gene ID: 319604, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Fam168aprovided by MGI
    Official Full Name
    family with sequence similarity 168, member Aprovided by MGI
    Primary source
    MGI:MGI:2442372
    See related
    Ensembl:ENSMUSG00000029461 AllianceGenome:MGI:2442372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0280; 2610030B18Rik; B930006L02Rik
    Summary
    Predicted to be involved in positive regulation of base-excision repair. Orthologous to human FAM168A (family with sequence similarity 168 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 32.8), CNS E18 (RPKM 31.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E2; 7 54.39 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (100355594..100490853)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (100706628..100841646)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family B (evectins) member 1 Neighboring gene predicted gene, 53385 Neighboring gene predicted gene, 35082 Neighboring gene STARR-seq mESC enhancer starr_19675 Neighboring gene STARR-seq mESC enhancer starr_19676 Neighboring gene STARR-seq mESC enhancer starr_19677 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2834 Neighboring gene RELT tumor necrosis factor receptor Neighboring gene STARR-positive B cell enhancer ABC_E4955 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene microRNA 3102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article
    2. A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Kalsotra A, et al. Proc Natl Acad Sci U S A, 2008 Dec 23. PMID 19075228, Free PMC Article
    3. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM168A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362169.1 → NP_001349098.1  protein FAM168A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK043083, BC079886, CJ101582
      Consensus CDS
      CCDS90280.1
      UniProtKB/Swiss-Prot
      Q3UVC2, Q80U50, Q8BGN7, Q8BGZ2
      UniProtKB/TrEMBL
      A0A140LIJ1
      Related
      ENSMUSP00000102657.3, ENSMUST00000107042.9
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 244
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. NM_001362170.1 → NP_001349099.1  protein FAM168A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK048559, BC079886, CJ101582
      Consensus CDS
      CCDS21505.1
      UniProtKB/TrEMBL
      A0A140LIJ1, Q68FE1
      Related
      ENSMUSP00000146851.2, ENSMUST00000207875.2
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 235
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. NM_178764.4 → NP_848879.1  protein FAM168A isoform 2

      See identical proteins and their annotated locations for NP_848879.1

      Status: VALIDATED

      Source sequence(s)
      BC079886, CJ101582
      Consensus CDS
      CCDS21505.1
      UniProtKB/TrEMBL
      A0A140LIJ1, Q68FE1
      Related
      ENSMUSP00000038233.8, ENSMUST00000049053.9
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 235
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      100355594..100490853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153165.1 → XP_036009058.1  protein FAM168A isoform X4

      Conserved Domains (1) summary
      pfam14944
      Location:1 → 193
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    2. XM_006507920.3 → XP_006507983.1  protein FAM168A isoform X2

      See identical proteins and their annotated locations for XP_006507983.1

      UniProtKB/Swiss-Prot
      Q3UVC2, Q80U50, Q8BGN7, Q8BGZ2
      UniProtKB/TrEMBL
      A0A140LIJ1
      Conserved Domains (1) summary
      pfam14944
      Location:1 → 244
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    3. XM_030242670.2 → XP_030098530.1  protein FAM168A isoform X1

      UniProtKB/TrEMBL
      A0A140LIJ1
      Conserved Domains (1) summary
      pfam14944
      Location:10 → 253
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1

    4. XM_036153164.1 → XP_036009057.1  protein FAM168A isoform X3

      UniProtKB/TrEMBL
      A0A140LIJ1
      Conserved Domains (1) summary
      pfam14944
      Location:10 → 244
      TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGZ2.1 GenPept UniProtKB/Swiss-Prot:Q8BGZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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