Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp11b1provided by MGI
Official Full Name: cytochrome P450, family 11, subfamily b, polypeptide 1provided by MGI
Primary source: MGI:MGI:88583
See related: Ensembl:ENSMUSG00000075604 AllianceGenome:MGI:88583
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FHI; CPN1; Cyp11b; Cyp11b-1
Summary: Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward adrenal adult (RPKM 843.1) See more
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Genomic context

Location:: 15 D3; 15 34.29 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74706741..74713492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74834892..74841643, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
Title: Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.
3-methylsulfonyl-DDE and related compounds did not alter Cyp11b1 gene expression in adrenocortical Y-1 cells indicating that compound-induced enzyme inhibition occurs on the protein level.
Title: Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.
Cyp11b1 null mouse, a model of congenital adrenal hyperplasia
Title: Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
These data showed that in the adrenal gland, PREB regulates the transcription of the CYP11B1 gene via cAMP.
Title: The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.
Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen.
Title: Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237323

Cyp11b1 (e-PCR), detects polymorphism
- UniSTS:474702

Cyp11b1 (e-PCR), detects polymorphism
- UniSTS:546712

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables corticosterone 18-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticosterone 18-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables steroid 11-beta-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 11-beta-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aldosterone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cortisol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glucocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucocorticoid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucocorticoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in steroid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450, family 11, subfamily b, polypeptide 1

Names: steroid-11-beta-hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033229.4 → NP_001028401.3 cytochrome P450, family 11, subfamily b, polypeptide 1

Status: VALIDATED

Source sequence(s)

AC139671

Consensus CDS

CCDS27535.1

Related

ENSMUSP00000127888.2, ENSMUST00000170259.3