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    Nt5m 5',3'-nucleotidase, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 103850, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nt5mprovided by MGI
    Official Full Name
    5',3'-nucleotidase, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1917127
    See related
    Ensembl:ENSMUSG00000032615 AllianceGenome:MGI:1917127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dNT-2; 2010013E09Rik
    Summary
    Enables 5'-nucleotidase activity. Acts upstream of or within dUMP catabolic process. Located in mitochondrion. Is expressed in several structures, including ear; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human NT5M (5',3'-nucleotidase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.3), adrenal adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nt5m in Genome Data Viewer
    Location:
    11 B1.3; 11 37.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59730233..59767359)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59847947..59876533)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene STARR-seq mESC enhancer starr_29631 Neighboring gene predicted gene 16062 Neighboring gene COP9 signalosome subunit 3 Neighboring gene predicted gene, 51946 Neighboring gene STARR-positive B cell enhancer ABC_E5233 Neighboring gene STARR-positive B cell enhancer ABC_E2354 Neighboring gene STARR-seq mESC enhancer starr_29632 Neighboring gene STARR-positive B cell enhancer ABC_E6991 Neighboring gene RIKEN cDNA 1810063I02 gene Neighboring gene predicted gene, 51900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs. Rampazzo C, et al. Gene, 2002 Jul 10. PMID 12234672
    2. Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike. Yan J, et al. Am J Hum Genet, 2007 Mar. PMID 17273973, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dUMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deoxyribonucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5'(3')-deoxyribonucleotidase, mitochondrial
    Names
    deoxy-5'-nucleotidase 2
    NP_001405279.1
    NP_001405281.1
    NP_001405282.1
    NP_001405283.1
    NP_001405284.1
    NP_598790.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418350.1 → NP_001405279.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC068808
      Related
      ENSMUST00000149076.8

    2. NM_001418352.1 → NP_001405281.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC068808

    3. NM_001418353.1 → NP_001405282.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC068808

    4. NM_001418354.1 → NP_001405283.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC068808

    5. NM_001418355.1 → NP_001405284.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC068808

    6. NM_134029.3 → NP_598790.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_598790.1

      Status: VALIDATED

      Source sequence(s)
      AC068808
      Consensus CDS
      CCDS24779.1
      UniProtKB/Swiss-Prot
      Q8VCE6
      Related
      ENSMUSP00000099756.4, ENSMUST00000102695.4
      Conserved Domains (2) summary
      pfam00702
      Location:30 → 160
      Hydrolase; haloacid dehalogenase-like hydrolase
      cl21460
      Location:30 → 219
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_184728.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    2. NR_184729.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    3. NR_184730.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    4. NR_184731.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    5. NR_184732.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    6. NR_184733.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    7. NR_184734.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    8. NR_184735.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    9. NR_184736.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068808

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59730233..59767359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCE6.1 GenPept UniProtKB/Swiss-Prot:Q8VCE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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