H2-Eb2 histocompatibility 2, class II antigen E beta2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H2-Eb2provided by MGI
Official Full Name: histocompatibility 2, class II antigen E beta2provided by MGI
Primary source: MGI:MGI:95902
See related: Ensembl:ENSMUSG00000067341 AllianceGenome:MGI:95902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ia5; Ia-5; H-2Eb2; Iebeta2; A130038H09Rik
Summary: Predicted to enable several functions, including MHC class II receptor activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to be located in external side of plasma membrane and immunological synapse. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and sarcoidosis (multiple). Orthologous to human HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) and HLA-DRB5 (major histocompatibility complex, class II, DR beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 5.4), thymus adult (RPKM 2.6) and 4 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34544477..34560384)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (34325503..34341410)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings suggest that the H2-E2 or RT1-D2 molecules could function as Ag-presenting molecules for a particular class of Ags, as modulators of Ag presentation like nonclassical nonpolymorphic class II molecules
Title: The Forgotten: Identification and Functional Characterization of MHC Class II Molecules H2-Eb2 and RT1-Db2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

ha2170 (e-PCR)
- UniSTS:515496

H2-Eb2 (e-PCR), detects polymorphism
- UniSTS:143308

D17Mit22 (e-PCR), detects polymorphism
- UniSTS:116471

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	ISO Inferred from Sequence Orthology more info
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables MHC class II receptor activity	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histocompatibility 2, class II antigen E beta2

Names: H-2 class II histocompatibility antigen E-a/k beta-2; MHC class II E-beta-2; MHC class II antigen E beta2; MHC class II antigen beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033978.3 → NP_001029150.1 histocompatibility 2, class II antigen E beta2

See identical proteins and their annotated locations for NP_001029150.1

Status: VALIDATED

Source sequence(s)

AK137912, CR974457

Consensus CDS

CCDS28646.1

UniProtKB/TrEMBL

Q3U060, Q3UUV9

Related

ENSMUSP00000056814.9, ENSMUST00000050325.10

Conserved Domains (2) summary

cd05766
Location:125 → 218

IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain

pfam00969
Location:42 → 115

MHC_II_beta; Class II histocompatibility antigen, beta domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

34544477..34560384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524489.5 → XP_006524552.1 histocompatibility 2, class II antigen E beta2 isoform X1

See identical proteins and their annotated locations for XP_006524552.1

UniProtKB/TrEMBL

Q3U060

Conserved Domains (3) summary

pfam00969
Location:42 → 115

MHC_II_beta; Class II histocompatibility antigen, beta domain

pfam06364
Location:226 → 282

DUF1068; Protein of unknown function (DUF1068)

cl11960
Location:125 → 218

Ig; Immunoglobulin domain
XM_006524490.5 → XP_006524553.1 histocompatibility 2, class II antigen E beta2 isoform X2

See identical proteins and their annotated locations for XP_006524553.1

UniProtKB/TrEMBL

Q3U060

Conserved Domains (2) summary

pfam00969
Location:42 → 115

MHC_II_beta; Class II histocompatibility antigen, beta domain

cl11960
Location:125 → 218

Ig; Immunoglobulin domain