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    Pde1a phosphodiesterase 1A, calmodulin-dependent [ Mus musculus (house mouse) ]

    Gene ID: 18573, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pde1aprovided by MGI
    Official Full Name
    phosphodiesterase 1A, calmodulin-dependentprovided by MGI
    Primary source
    MGI:MGI:1201792
    See related
    Ensembl:ENSMUSG00000059173 AllianceGenome:MGI:1201792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in signal transduction. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE1A (phosphodiesterase 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 19.1), frontal lobe adult (RPKM 12.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C3; 2 47.64 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79664797..80026862, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79834453..80196522, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2625 Neighboring gene ITPR interacting domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_04937 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1C Neighboring gene STARR-seq mESC enhancer starr_04938 Neighboring gene STARR-seq mESC enhancer starr_04939 Neighboring gene predicted gene, 54166 Neighboring gene STARR-seq mESC enhancer starr_04941 Neighboring gene STARR-seq mESC enhancer starr_04942 Neighboring gene STARR-seq mESC enhancer starr_04943 Neighboring gene predicted gene 13674 Neighboring gene STARR-positive B cell enhancer ABC_E5939 Neighboring gene predicted gene, 36153 Neighboring gene peroxiredoxin 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy. Zhang H, et al. Sci Adv, 2019 May. PMID 31131329, Free PMC Article
    2. Generation and phenotypic characterization of Pde1a mutant mice. Wang X, et al. PLoS One, 2017. PMID 28750036, Free PMC Article
    3. Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Miller CL, et al. Circ Res, 2009 Nov 6. PMID 19797176, Free PMC Article
    4. Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm. Vasta V, et al. Biol Reprod, 2005 Oct. PMID 15901640
    5. Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival. Nagel DJ, et al. Circ Res, 2006 Mar 31. PMID 16514069, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDE1 inhibition induces PKA- and PKG-mediated promotion of proteasomal degradation of misfolded proteins and treats heart failure with preserved ejection fraction caused by CryAB(R120G) in a mouse model of cardiac proteinopathy
      Title: PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
    2. These results support an important role of PDE1A in the renal pathogenesis of autosomal dominant polycystic kidney disease and in the regulation of blood pressure.
      Title: Generation and phenotypic characterization of Pde1a mutant mice.
    3. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
      Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
    4. These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
      Title: Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
    5. a novel role for Ca(2+)/CaM-stimulated PDE1, particularly PDE1A, in regulating pathological cardiomyocyte hypertrophy via a cGMP/PKG-dependent mechanism, thereby demonstrating Ca(2+) and cGMP signaling cross-talk during cardiac hypertrophy.
      Title: Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.
    6. PDE1A is important in VSMC growth and survival and may contribute to the neointima formation in atherosclerosis and restenosis.
      Title: Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.
    7. new variant PDE1A_v7 is the major form of cyclic nucleotide phosphodiesterase 1A expressed in mature sperm and is therefore likely to play an important role in cyclic nucleotide regulation of mature sperm function.
      Title: Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (6)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116577

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    61 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    cam-PDE 1A
    NP_001009978.1
    NP_001009979.1
    NP_001153054.1
    NP_001342069.1
    NP_001342070.1
    NP_001342071.1
    NP_001342073.1
    NP_001407456.1
    NP_001407458.1
    NP_058024.2
    XP_006498982.1
    XP_030104296.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009978.2 → NP_001009978.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7

      See identical proteins and their annotated locations for NP_001009978.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (7) has shorter and distinct N- and C-termini compared to isoform 2.
      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS16173.1
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099712.4, ENSMUST00000102652.10
      Conserved Domains (2) summary
      pfam00233
      Location:150 → 366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:9 → 65
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_001009979.2 → NP_001009979.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

      See identical proteins and their annotated locations for NP_001009979.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' and 3' ends (UTR and coding sequence) compared to variant 1. The resulting isoform (9) has shorter and distinct N- and C-termini compared to isoform 2.
      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS16174.1
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099711.4, ENSMUST00000102651.10
      Conserved Domains (2) summary
      pfam00233
      Location:150 → 366
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:9 → 65
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. NM_001159582.2 → NP_001153054.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      See identical proteins and their annotated locations for NP_001153054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (2). Variants 1, 2, 10, and 11 all encode isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099713.2, ENSMUST00000102653.8
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. NM_001355140.2 → NP_001342069.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, and 11, encodes isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. NM_001355141.2 → NP_001342070.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, and 10, encodes isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. NM_001355142.2 → NP_001342071.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL844577, AL928607, AL928811
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. NM_001355144.2 → NP_001342073.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL928607
      Consensus CDS
      CCDS89501.1
      UniProtKB/TrEMBL
      A2ASF9, F6X0V1
      Related
      ENSMUSP00000088260.5, ENSMUST00000090756.11
      Conserved Domains (2) summary
      pfam00233
      Location:114 → 330
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:14 → 29
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. NM_001420527.1 → NP_001407456.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL928607, AL928811

    9. NM_001420529.1 → NP_001407458.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL928607, AL928811

    10. NM_016744.5 → NP_058024.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      See identical proteins and their annotated locations for NP_058024.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 10, and 11 all encode isoform 2.
      Source sequence(s)
      AL844577, AL928607, AL928811
      Consensus CDS
      CCDS16172.1
      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Related
      ENSMUSP00000099715.4, ENSMUST00000102655.10
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      79664797..80026862 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498919.4 → XP_006498982.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      See identical proteins and their annotated locations for XP_006498982.1

      UniProtKB/Swiss-Prot
      E9Q6V1, O35388, Q5I7S8, Q61481, Q8BRR9, Q9JLL9
      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. XM_030248436.2 → XP_030104296.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      F6X0V1
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001355143.1: Suppressed sequence

      Description
      NM_001355143.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61481.3 GenPept UniProtKB/Swiss-Prot:Q61481

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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