Slco1a1 solute carrier organic anion transporter family, member 1a1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco1a1provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 1a1provided by RGD
Primary source: RGD:3700
See related: Ensembl:ENSRNOG00000036984 AllianceGenome:RGD:3700
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatp1; OATP-1; Slc21a1; Slc21a3
Summary: Predicted to enable bile acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of plasma membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 527.7) and Kidney (RPKM 286.3) See more
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Genomic context

Location:: 4q44

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176606924..176682027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (174877045..174950900, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176158174..176231331, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

optimal rOATP1A4 trafficking to the cell surface is dependent upon coexpression and interaction with rOATP1A1.
Title: Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation and Trafficking to the Hepatocyte Plasma Membrane.
Bile transporters OATP1/MRP2 mRNA expression ratio in liver tissue decreased with dimethylnitrosamine-induced liver injury, model of liver cirrhosis.
Title: Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis.
Oatp1a1 has a role in acute liver congestion as seen in gadoxetate disodium-enhanced MRI
Title: Features of acute liver congestion on gadoxetate disodium-enhanced MRI in a rat model: Role of organic anion-transporting polypeptide 1A1.
These findings suggest the possibility that ABCC2-mediated hepatobiliary excretion and OATP1/OATP2-mediated hepatic uptake do not play important roles in the disposition of regorafenib.
Title: Lack of Contribution of Multidrug Resistance-associated Protein and Organic Anion-transporting Polypeptide to Pharmacokinetics of Regorafenib, a Novel Multi-Kinase Inhibitor, in Rats.
Oatp1a1 and Oatp2b1 expression levels are decreased by intestinal ischemia reperfusion.
Title: Intestinal ischemia-reperfusion suppresses biliary excretion of hepatic organic anion transporting polypeptides substrate.
persistent elevation of serum bilirubin during regeneration of small liver was suggested to be due to sustained low uptake from the sinusoids by repressed OATP1 and low export from hepatocytes to bile duct by repressed MRP2 on the canalicular membrane.
Title: Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats.
Although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools.
Title: PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.
Insights of this protein in kidneyin its cellular localization and response during ischemic acute kidney injury and recovery from it.
Title: Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion.
Topology and glycosylation of rat hepatocyte Oatp1a1 was examined.
Title: Topological assessment of oatp1a1: a 12-transmembrane domain integral membrane protein with three N-linked carbohydrate chains.
this is the first report suggesting that HGF regulates Oatp1 protein level and that the ameliorative effects of HGF in cholestasis was induced, at least in part, by correcting the down-regulation of the Oatp1 protein level
Title: Hepatocyte growth factor increases uptake of estradiol 17beta-D-glucuronide and Oatp1 protein level in rat hepatocytes.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

RH139685 (e-PCR)
- UniSTS:221769

PMC19316P1 (e-PCR)
- UniSTS:271748

D4Rat288 (e-PCR), detects polymorphism
- UniSTS:227829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in organic anion transport	TAS Traceable Author Statement more info	PubMed
involved_in response to stilbenoid	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1A1

Names: organic anion-transporting polypeptide 1; sodium-independent organic anion transporter 1; solute carrier family (organic anion transporter) member 1; solute carrier family (organic anion transporter) member 3; solute carrier family 21 member 1; solute carrier organic anion transporter family member 1A1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017111.2 → NP_058807.1 solute carrier organic anion transporter family member 1A1

See identical proteins and their annotated locations for NP_058807.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P46720

UniProtKB/TrEMBL

A0A8I5ZY22, A6IMP9

Related

ENSRNOP00000078030.1, ENSRNOT00000102966.1

Conserved Domains (3) summary

cd06174
Location:40 → 408

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:436 → 488

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

TIGR00805
Location:1 → 625

oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

176606924..176682027 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286619.1 → XP_063142689.1 solute carrier organic anion transporter family member 1A1 isoform X1

UniProtKB/Swiss-Prot

P46720

UniProtKB/TrEMBL

A6IMP9
XM_063286621.1 → XP_063142691.1 solute carrier organic anion transporter family member 1A1 isoform X3
XM_063286620.1 → XP_063142690.1 solute carrier organic anion transporter family member 1A1 isoform X2