Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnj10provided by RGD
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 10provided by RGD
Primary source: RGD:61822
See related: Ensembl:ENSRNOG00000068444 AllianceGenome:RGD:61822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity and signaling receptor binding activity. Involved in several processes, including membrane hyperpolarization; potassium ion import across plasma membrane; and response to corticosteroid. Located in several cellular components, including astrocyte projection; basolateral plasma membrane; and microvillus. Used to study diabetic retinopathy. Biomarker of amyotrophic lateral sclerosis; brain disease (multiple); eye disease (multiple); and sensorineural hearing loss. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 66.1), Kidney (RPKM 44.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87334510..87367747)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84802026..84835383)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90722945..90753338)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[IL-6 promotes the activation of rat astrocytes and down-regulation of the expression of Kir4.1 channel].
Title: [IL-6 promotes the activation of rat astrocytes and down-regulation of the expression of Kir4.1 channel].
Dysfunction of oligodendrocyte inwardly rectifying potassium channel in a rat model of amyotrophic lateral sclerosis.
Title: Dysfunction of oligodendrocyte inwardly rectifying potassium channel in a rat model of amyotrophic lateral sclerosis.
Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines.
Title: Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines.
he down-regulation of Kir4.1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation.
Title: Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
H3K9me2 and G9a are sensitive to epileptic seizure activity during the acute phase of epilepsy and can affect the transcriptional regulation of the Kcnj10 (Kir4.1) channel.
Title: Dimethylation of Histone 3 Lysine 9 is sensitive to the epileptic activity, and affects the transcriptional regulation of the potassium channel Kcnj10 gene in epileptic rats.
studies suggest that AGE-modification of laminin is detrimental to Kir4.1 channels. By studying the role of AGEs in Kir4.1 channels we have identified a novel mechanism of Muller cell dysfunction and its subsequent involvement in Diabetic retinopathy.
Title: Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells.
IL-1beta promotes the proliferation of cultured astrocytes by influencing the expression of Kir4.1.
Title: [IL-1β promotes the proliferation of astrocytes and downregulates the expression of Kir4.1].
Kir4.1 channels possess a diurnal rhythm, and this rhythm is dampened with diabetes, thereby suggesting that the increase in TNF-alpha is detrimental to normal Kir4.1 rhythm and expression.
Title: Tumor Necrosis Factor Alpha (TNF-α) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina.
This study demonstrated changes in Kir4.1 expression in an animal model of PTS in the acute and chronic stages of the condition.
Title: Inwardly rectifying potassium channel 4.1 expression in post-traumatic syringomyelia.
This study demonstrated that Kir4.1 developmental expression both in the cortex and hippocampus and support the glial role of Kir4.1 in K(+) spatial buffering.
Title: Developmental expression of Kir4.1 in astrocytes and oligodendrocytes of rat somatosensory cortex and hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (41)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-glutamate import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult walking behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to potassium ion	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in glutamate reuptake	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glutamate reuptake	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of resting membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to blue light	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mineralocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	IEA Inferred from Electronic Annotation more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
is_active_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 10

Names: ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; brain-specific inwardly rectifying K(+) channel 1; inward rectifier K(+) channel Kir4.1; kir4.1; potassium channel, inwardly rectifying subfamily J member 10; potassium voltage-gated channel subfamily J member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031602.2 → NP_113790.2 ATP-sensitive inward rectifier potassium channel 10

See identical proteins and their annotated locations for NP_113790.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P49655, Q62790

UniProtKB/TrEMBL

A0A8I6G3K4, A6JG53

Related

ENSRNOP00000086322.1, ENSRNOT00000119639.1

Conserved Domains (2) summary

pfam01007
Location:31 → 172

IRK; Inward rectifier potassium channel

pfam17655
Location:179 → 354

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

87334510..87367747

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090649.2 → XP_038946577.2 ATP-sensitive inward rectifier potassium channel 10 isoform X2
XM_039090648.2 → XP_038946576.2 ATP-sensitive inward rectifier potassium channel 10 isoform X1