Gab1 GRB2-associated binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gab1provided by RGD
Official Full Name: GRB2-associated binding protein 1provided by RGD
Primary source: RGD:1311085
See related: Ensembl:ENSRNOG00000017879 AllianceGenome:RGD:1311085
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 124.9), Kidney (RPKM 123.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (44035693..44143617)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (27131262..27239236)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (30794290..30903819)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
Title: Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
A novel role of GAB1 and its down-stream signaling PI3K/AKT.
Title: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis.
using an in vitro model, we demonstrated that overexpressing Gab1 in neonatal cardiomyocytes, under hypoxic condition, resulted in the reduction of apoptosis suggesting a role for this protein in cardiomyocyte survival
Title: Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes.
While EGF activated Gab1 and Shc equally, within the same concentration range, HGF very potently and almost exclusively activated Gab1, having only a minimal effect on Shc
Title: The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes.
Report role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
Title: A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
role of Grb2-associated binder-1 (Gab1) in signaling pathways downstream of growth factor receptors.
Title: Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
Gab1 activation plays a central role in HGF's ability to stimulate intracellular transduction cascades in pancreatic acinar cells and this action likely plays a key role in HGF's ability to alter pancreatic cell function (i.e., growth/regeneration).
Title: Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
Gab1, considered a physiological activator of protein tyrosine phosphatase SHP2, increases cell motility in the presence but not the absence of insulin.
Title: Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135107 (e-PCR)
- UniSTS:218384

AA555564 (e-PCR)
- UniSTS:206909

BF390263 (e-PCR)
- UniSTS:249421

UniSTS:235942 (e-PCR)
- UniSTS:235942

RH127625 (e-PCR)
- UniSTS:210935

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in response to hepatocyte growth factor	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GRB2-associated-binding protein 1

Names: growth factor receptor bound protein 2-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108444.1 → NP_001101914.1 GRB2-associated-binding protein 1

See identical proteins and their annotated locations for NP_001101914.1

Status: PROVISIONAL

Source sequence(s)

CH473972

UniProtKB/TrEMBL

A0A0G2JZD5, A6IYG9, C6JUQ2

Related

ENSRNOP00000071006.2, ENSRNOT00000083219.2

Conserved Domains (2) summary

cd01266
Location:3 → 125

PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain

pfam00169
Location:6 → 115

PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

44035693..44143617

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097824.2 → XP_038953752.1 GRB2-associated-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JZD5, C6JUQ2

Conserved Domains (1) summary

cl17171
Location:1 → 22

PH-like; Pleckstrin homology-like domain
XM_039097821.2 → XP_038953749.1 GRB2-associated-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JZD5, C6JUQ2, D3ZAL7

Related

ENSRNOP00000024390.4

Conserved Domains (1) summary

cd01266
Location:3 → 125

PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain
XM_063278117.1 → XP_063134187.1 GRB2-associated-binding protein 1 isoform X3
XM_039097823.2 → XP_038953751.1 GRB2-associated-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A0G2JZD5, C6JUQ2

Conserved Domains (1) summary

cl17171
Location:1 → 22

PH-like; Pleckstrin homology-like domain
XM_063278118.1 → XP_063134188.1 GRB2-associated-binding protein 1 isoform X4

UniProtKB/TrEMBL

A0A0G2JZD5, C6JUQ2