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    Usp20 ubiquitin specific peptidase 20 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311856, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Usp20provided by RGD
    Official Full Name
    ubiquitin specific peptidase 20provided by RGD
    Primary source
    RGD:1305621
    See related
    Ensembl:ENSRNOG00000007710 AllianceGenome:RGD:1305621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor binding activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein K48-linked deubiquitination; protein K63-linked deubiquitination; and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in centrosome. Predicted to be active in cytoplasm. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 96.3), Brain (RPKM 84.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp20 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34670613..34704156)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14272737..14306409)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9822586..9856057)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene torsin family 1, member A Neighboring gene similar to human chromosome 9 open reading frame 78 Neighboring gene formin binding protein 1 Neighboring gene U12 minor spliceosomal RNA Neighboring gene G protein-coupled receptor 107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary. Zhang X, et al. Biol Trace Elem Res, 2016 Dec. PMID 27156111
    2. The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization. Berthouze M, et al. EMBO J, 2009 Jun 17. PMID 19424180, Free PMC Article
    3. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Li J, et al. Nature, 2013 Mar 14. PMID 23486064, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 20
    Names
    ubiquitin specific protease 20
    NP_001101297.1
    XP_006233978.1
    XP_017447337.1
    XP_038961173.1
    XP_038961174.1
    XP_038961175.1
    XP_063140032.1
    XP_063140033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107827.3 → NP_001101297.1  ubiquitin carboxyl-terminal hydrolase 20

      See identical proteins and their annotated locations for NP_001101297.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AC85, A6JU13, D3ZLQ8
      Related
      ENSRNOP00000010786.5, ENSRNOT00000010786.8
      Conserved Domains (3) summary
      smart00695
      Location:811 → 895
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 260
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:145 → 683
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34670613..34704156
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105246.2 → XP_038961174.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AC85, A0A8I6ARX9
      Related
      ENSRNOP00000097493.1
      Conserved Domains (3) summary
      smart00695
      Location:793 → 877
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 242
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:127 → 665
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. XM_039105247.2 → XP_038961175.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AC85
      Conserved Domains (2) summary
      smart00695
      Location:665 → 749
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:2 → 537
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_063283963.1 → XP_063140033.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X3

    4. XM_039105245.2 → XP_038961173.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AC85, A6JU13, D3ZLQ8
      Conserved Domains (3) summary
      smart00695
      Location:811 → 895
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 260
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:145 → 683
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. XM_063283962.1 → XP_063140032.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

      UniProtKB/TrEMBL
      A6JU13, D3ZLQ8

    6. XM_006233916.5 → XP_006233978.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

      See identical proteins and their annotated locations for XP_006233978.1

      UniProtKB/TrEMBL
      A0A8I6AC85, A6JU13, D3ZLQ8
      Conserved Domains (3) summary
      smart00695
      Location:811 → 895
      DUSP; Domain in ubiquitin-specific proteases
      COG5207
      Location:8 → 260
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      pfam00443
      Location:145 → 683
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. XM_017591848.3 → XP_017447337.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AC85
      Conserved Domains (2) summary
      smart00695
      Location:665 → 749
      DUSP; Domain in ubiquitin-specific proteases
      pfam00443
      Location:2 → 537
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein Strain
    Heading Accession and Version

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