F8 coagulation factor VIII [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F8provided by RGD
Official Full Name: coagulation factor VIIIprovided by RGD
Primary source: RGD:727845
See related: Ensembl:ENSRNOG00000031197 AllianceGenome:RGD:727845
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 92.8), Heart (RPKM 64.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p13

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (155237..187186)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (140848..172330)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (367862..399242, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of a F8(-/-) rat model of hemophilic arthropathy reveals that collagen turnover is altered
Title: Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia.
analysis of animal models for hemophilia A and the advantage of rats over mice in the factor VIII gene mutation model
Title: WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A.
Sequence of the rat factor VIII cDNA
Title: Sequence of the rat factor VIII cDNA.

Submit: New GeneRIF Correction

General gene information

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Markers

BI275668 (e-PCR)
- UniSTS:249644

AI234173 (e-PCR)
- UniSTS:250212

RH139018 (e-PCR)
- UniSTS:221104

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation, intrinsic pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation, intrinsic pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coagulation factor VIII

Names: coagulation factor VIII, procoagulant component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183331.2 → NP_899160.2 coagulation factor VIII precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D3ZEB1, Q7TN96

Related

ENSRNOP00000050792.5, ENSRNOT00000045926.5

Conserved Domains (2) summary

cd00057
Location:2103 → 2251

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

cl19115
Location:387 → 563

Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

155237..187186

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277282.1 → XP_063133352.1 coagulation factor VIII isoform X1
XM_063277283.1 → XP_063133353.1 coagulation factor VIII isoform X2
XM_039096756.2 → XP_038952684.1 coagulation factor VIII isoform X3

UniProtKB/TrEMBL

Q7TN96

Conserved Domains (1) summary

cl19115
Location:387 → 563

Cupredoxin; Cupredoxin superfamily
XM_039096757.2 → XP_038952685.1 coagulation factor VIII isoform X4

Conserved Domains (1) summary

cl19115
Location:387 → 563

Cupredoxin; Cupredoxin superfamily
XM_063277284.1 → XP_063133354.1 coagulation factor VIII isoform X5
XM_063277285.1 → XP_063133355.1 coagulation factor VIII isoform X6