C3 complement C3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C3provided by RGD
Official Full Name: complement C3provided by RGD
Primary source: RGD:2232
See related: Ensembl:ENSRNOG00000046834 AllianceGenome:RGD:2232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables lipid binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; response to estradiol; and response to steroid hormone. Located in extracellular space. Used to study glomerulonephritis; membranous glomerulonephritis; obesity; pneumonia; and pre-eclampsia. Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); eye disease (multiple); pneumocystosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 17340.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (2174412..2201339, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (2087437..2114366, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (9721137..9747084)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
Title: Inhibition of C3a/C3aR Axis in Diverse Stages of Ulcerative Colitis Affected the Prognosis of UC by Modulating the Pyroptosis and Expression of Caspase-11.
Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitude.
Title: Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitude.
Increased Complement 3 With Suppression of miR-145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats.
Title: Increased Complement 3 With Suppression of miR-145 Induces the Synthetic Phenotype in Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats.
Increased C3 induces salt-sensitive hypertension with increases in urinary catecholamine excretion and intrarenal activation of the renin-angiotensin system by the dedifferentiation of mesenchymal tissues in kidney from spontaneously hypertensive rats.
Title: Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats.
These data suggest that locally produced C3 is an important prosurvival mechanism in pancreatic beta-cells under a proinflammatory assault.
Title: Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis.
Inhibition of C3 might improve the reactivity of superior mesenteric arteries to norepinephrine during hemorrhagic shock possibly through the downregulation of NO, ET1, TNF-alpha and reactive oxygen radicals.
Title: Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model.
Recruited microglia/monocytes contribute to activation of complement in the aging retina, through local expression of C3 mRNA.
Title: Synthesis and propagation of complement C3 by microglia/monocytes in the aging retina.
The C3 and C3a receptor system may primarily be involved in the pathogenesis of renal remodeling in hypertensive rats.
Title: Role of complement 3a in the growth of mesangial cells from stroke-prone spontaneously hypertensive rats.
The expression of the complement component C3f and the complement component 4A have potential for use in post-transplant diagnosis of rejection.
Title: Proteomic profiling of heterotopic heart-transplanted rats using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry: potential biomarkers and drug targets.
Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain.
Title: Abnormal activation of complement C3 in the spinal dorsal horn is closely associated with progression of neuropathic pain.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C3 (e-PCR), detects polymorphism
- UniSTS:257037

D17Mit88 (e-PCR), detects polymorphism
- UniSTS:128113

AU049381 (e-PCR)
- UniSTS:145828

RH130704 (e-PCR)
- UniSTS:213988

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C5L2 anaphylatoxin chemotactic receptor binding	IEA Inferred from Electronic Annotation more info
enables C5L2 anaphylatoxin chemotactic receptor binding	ISO Inferred from Sequence Orthology more info
enables C5L2 anaphylatoxin chemotactic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	TAS Traceable Author Statement more info	PubMed
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in complement-dependent cytotoxicity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in complement-mediated synapse pruning	IEA Inferred from Electronic Annotation more info
involved_in complement-mediated synapse pruning	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in neuron remodeling	IEA Inferred from Electronic Annotation more info
involved_in neuron remodeling	ISO Inferred from Sequence Orthology more info
involved_in oviduct epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oviduct epithelium development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of activation of membrane attack complex	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activation of membrane attack complex	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of developmental growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid storage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type IIa hypersensitivity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of type IIa hypersensitivity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in tolerance induction	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in vertebrate eye-specific patterning	IEA Inferred from Electronic Annotation more info
involved_in vertebrate eye-specific patterning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C3

Names: complement component 3

NP_058690.2

EC 3.4.21.43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016994.2 → NP_058690.2 complement C3 precursor

See identical proteins and their annotated locations for NP_058690.2

Status: VALIDATED

Source sequence(s)

BI281644, CK366193, CO565011, CO569380, CO796620, CO800063, JAXUCZ010000009, X52477

UniProtKB/Swiss-Prot

P01026, Q9ET19, Q9QV57, Q9QV58

UniProtKB/TrEMBL

A6KQR3, M0RBJ7

Related

ENSRNOP00000066934.2, ENSRNOT00000075494.2

Conserved Domains (10) summary

cd00017
Location:678 → 747

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:996 → 1282

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

cd03583
Location:1513 → 1661

NTR_complement_C3; NTR/C345C domain, complement C3 subfamily; The NTR domain found in complement C3 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C3 plays a pivotal role in the activation of the complement ...

pfam00207
Location:770 → 866

A2M; Alpha-2-macroglobulin family

pfam01835
Location:129 → 224

A2M_N; MG2 domain

pfam07677
Location:1398 → 1493

A2M_recep; A-macroglobulin receptor

pfam07703
Location:455 → 604

A2M_N_2; Alpha-2-macroglobulin family N-terminal region

pfam17789
Location:355 → 445

MG4; Macroglobulin domain MG4

pfam17790
Location:26 → 124

MG1; Macroglobulin domain MG1

pfam17791
Location:226 → 307

MG3; Macroglobulin domain MG3