Eif3c eukaryotic translation initiation factor 3, subunit C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif3cprovided by RGD
Official Full Name: eukaryotic translation initiation factor 3, subunit Cprovided by RGD
Primary source: RGD:1308871
See related: Ensembl:ENSRNOG00000018761 AllianceGenome:RGD:1308871
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eif3s8; eIF3 p110
Summary: Predicted to enable ribosome binding activity and translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Orthologous to several human genes including EIF3CL (eukaryotic translation initiation factor 3 subunit C like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 522.4), Thymus (RPKM 508.9) and 9 other tissues See more
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Genomic context

Location:: 1q36

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190565183..190583067, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181134604..181152489, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197964406..197982917, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation initiation factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit C

Names: eukaryotic translation initiation factor 3 subunit 8; eukaryotic translation initiation factor 3, subunit 8, 110kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100662.1 → NP_001094132.1 eukaryotic translation initiation factor 3 subunit C

See identical proteins and their annotated locations for NP_001094132.1

Status: PROVISIONAL

Source sequence(s)

BC169011

UniProtKB/Swiss-Prot

B5DFC8, Q3MIB2

UniProtKB/TrEMBL

A0A8I6G7D4

Related

ENSRNOP00000025782.4, ENSRNOT00000025782.7

Conserved Domains (2) summary

smart00753
Location:776 → 864

PAM; PCI/PINT associated module

pfam05470
Location:29 → 703

eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus