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    sik2b salt-inducible kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 567919, updated on 27-Mar-2024

    Summary

    Official Symbol
    sik2bprovided by ZNC
    Official Full Name
    salt-inducible kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071012-1
    See related
    Ensembl:ENSDARG00000062315 AllianceGenome:ZFIN:ZDB-GENE-071012-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    snf1lk2b
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular response to glucose starvation; intracellular signal transduction; and protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human SIK2 (salt inducible kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    Location:
    chromosome: 15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (21781764..21837001, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21846033..21901271, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene NKAP domain containing 1 Neighboring gene protein phosphatase 2, regulatory subunit A, beta b Neighboring gene layilin b Neighboring gene zona pellucida-like domain-containing protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase SIK2
    Names
    SNF1-like kinase 2b
    XP_696325.5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      21781764..21837001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_691233.8XP_696325.5  serine/threonine-protein kinase SIK2

      UniProtKB/TrEMBL
      A0A8N7URB1, E7F378
      Related
      ENSDARP00000084386.4, ENSDART00000089953.6
      Conserved Domains (3) summary
      smart00220
      Location:22273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14409
      Location:299343
      UBA_SIK2; UBA domain found in salt-inducible kinase 2 (SIK2)
      cd14071
      Location:21273
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases