igfbp2a insulin-like growth factor binding protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igfbp2aprovided by ZNC
Official Full Name: insulin-like growth factor binding protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000125-12
See related: Ensembl:ENSDARG00000052470 AllianceGenome:ZFIN:ZDB-GENE-000125-12
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: igfbp2; igfbp2b
Summary: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in negative regulation of DNA replication; negative regulation of developmental growth; and regulation of insulin-like growth factor receptor signaling pathway. Acts upstream of or within circulatory system development; negative regulation of cell population proliferation; and regulation of growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; gonad; head; immature eye; and yolk syncytial layer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (20921546..20952178, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (18861324..18891956, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The identification and characterization of two IGFBP-2 genes in zebrafish and four other teleost fish, is reported.
Title: Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.
IGFBP-2 is required for general embryonic development and growth and plays a local role in regulating vascular development in a model vertebrate organism.
Title: Targeted knockdown of insulin-like growth factor binding protein-2 disrupts cardiovascular development in zebrafish embryos.
The igfbp2(30-32kDa)is similarities to mammalian size.
Title: Insulin-like growth factor signaling in fish.

Submit: New GeneRIF Correction

General gene information

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Markers

igfbp.af198033 (e-PCR)
- UniSTS:205593

G39402 (e-PCR)
- UniSTS:9508

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin-like growth factor binding	IDA Inferred from Direct Assay more info
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 2-A

Names: IGF-binding protein 2-A; IGFBP-2-A; IGFBP-2a; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131458.2 → NP_571533.1 insulin-like growth factor-binding protein 2-A precursor

See identical proteins and their annotated locations for NP_571533.1

Status: PROVISIONAL

Source sequence(s)

AF198033

UniProtKB/Swiss-Prot

A8E5I5, Q9PTH3

Related

ENSDARP00000068816.4, ENSDART00000074327.5

Conserved Domains (2) summary

smart00121
Location:26 → 102

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:180 → 259

Thyroglobulin_1; Thyroglobulin type-1 repeat