Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chac2provided by RGD
Official Full Name: ChaC glutathione specific gamma-glutamylcyclotransferase 2provided by RGD
Primary source: RGD:1309120
See related: Ensembl:ENSRNOG00000070799 AllianceGenome:RGD:1309120
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309120
Summary: Predicted to enable gamma-glutamylcyclotransferase activity. Predicted to be involved in glutathione catabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 112.9), Spleen (RPKM 77.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (108921669..108929215, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (104720754..104728305, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (115383906..115391757, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

UniSTS:236546 (e-PCR)
- UniSTS:236546

RH144302 (e-PCR)
- UniSTS:233547

RH134469 (e-PCR)
- UniSTS:217749

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione specific gamma-glutamylcyclotransferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione specific gamma-glutamylcyclotransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative glutathione-specific gamma-glutamylcyclotransferase 2

Names: ChaC cation transport regulator 2; ChaC, cation transport regulator homolog 2; cation transport regulator-like protein 2; gamma-GCG 2

NP_001020187.1

EC 4.3.2.7

XP_008768686.1

EC 4.3.2.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.