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    Rhod ras homolog family member D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293660, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rhodprovided by RGD
    Official Full Name
    ras homolog family member Dprovided by RGD
    Primary source
    RGD:1310985
    See related
    Ensembl:ENSRNOG00000019220 AllianceGenome:RGD:1310985
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; focal adhesion assembly; and lamellipodium assembly. Predicted to act upstream of or within protein targeting. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 101.1), Kidney (RPKM 69.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rhod in Genome Data Viewer
    Location:
    1q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211138126..211153953, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201708699..201724405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219668352..219682287, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene lysine demethylase 2A Neighboring gene small nucleolar RNA SNORA32 Neighboring gene uncharacterized LOC134483956 Neighboring gene synaptotagmin 12 Neighboring gene solute carrier family 25 member 5, pseudogene 10 Neighboring gene similar to human chromosome 11 open reading frame 86

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. Nehru V, et al. Biochem Biophys Res Commun, 2013 Apr 5. PMID 23454120
    2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Gad AK, et al. Mol Biol Cell, 2012 Dec. PMID 23087206, Free PMC Article
    3. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Karner CM, et al. Nat Genet, 2009 Jul. PMID 19543268, Free PMC Article
    4. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. Sandilands E, et al. J Cell Sci, 2007 Aug 1. PMID 17623777
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to fibroblast growth factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho-related GTP-binding protein RhoD
    Names
    ras homolog gene family, member D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106323.1 → NP_001099793.1  rho-related GTP-binding protein RhoD

      See identical proteins and their annotated locations for NP_001099793.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HYX3, D4ADM8
      Related
      ENSRNOP00000026092.3, ENSRNOT00000026092.5
      Conserved Domains (1) summary
      cd04132
      Location:16 → 210
      Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211138126..211153953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108298.2 → XP_038964226.1  rho-related GTP-binding protein RhoD isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:2 → 151
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039108286.2 → XP_038964214.1  rho-related GTP-binding protein RhoD isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:2 → 151
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_039108296.2 → XP_038964224.1  rho-related GTP-binding protein RhoD isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:2 → 151
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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