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    Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 [ Mus musculus (house mouse) ]

    Gene ID: 70604, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dnajb14provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B14provided by MGI
    Primary source
    MGI:MGI:1917854
    See related
    Ensembl:ENSMUSG00000074212 AllianceGenome:MGI:1917854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730496F10Rik
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB14 (DnaJ heat shock protein family (Hsp40) member B14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.5), cerebellum adult (RPKM 6.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajb14 in Genome Data Viewer
    Location:
    3 G3; 3 63.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137572801..137619350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137867675..137916563)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:137527362-137527471 Neighboring gene STARR-positive B cell enhancer ABC_E4600 Neighboring gene predicted gene 43403 Neighboring gene STARR-seq mESC enhancer starr_09095 Neighboring gene H2A.Z variant histone 1 Neighboring gene predicted gene, 40155 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9081 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene STARR-positive B cell enhancer ABC_E9226 Neighboring gene predicted gene, 19708 Neighboring gene STARR-seq mESC enhancer starr_09102 Neighboring gene STARR-positive B cell enhancer ABC_E6138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel mammalian ER-located J-protein, DNAJB14, can accelerate ERAD of misfolded membrane proteins. Sopha P, et al. Cell Struct Funct, 2012. PMID 23018488
    2. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 14
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033155.1 → NP_001028327.1  dnaJ homolog subfamily B member 14

      See identical proteins and their annotated locations for NP_001028327.1

      Status: VALIDATED

      Source sequence(s)
      AC125154, AC146607
      Consensus CDS
      CCDS51077.1
      UniProtKB/Swiss-Prot
      Q149L6, Q3TU54, Q3UTE5
      Related
      ENSMUSP00000087641.6, ENSMUST00000090178.10
      Conserved Domains (3) summary
      COG0484
      Location:107 → 214
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:108 → 169
      DnaJ; DnaJ domain
      pfam09320
      Location:271 → 371
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      137572801..137619350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163304.1 → XP_036019197.1  dnaJ homolog subfamily B member 14 isoform X2

      Conserved Domains (1) summary
      COG0484
      Location:107 → 214
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. XM_006502056.3 → XP_006502119.1  dnaJ homolog subfamily B member 14 isoform X3

      Conserved Domains (2) summary
      COG0484
      Location:40 → 147
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam09320
      Location:204 → 304
      DUF1977; Domain of unknown function (DUF1977)

    3. XM_006502055.3 → XP_006502118.1  dnaJ homolog subfamily B member 14 isoform X1

      UniProtKB/Swiss-Prot
      Q149L6
      Conserved Domains (2) summary
      COG0484
      Location:57 → 164
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam09320
      Location:221 → 321
      DUF1977; Domain of unknown function (DUF1977)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q149L6.1 GenPept UniProtKB/Swiss-Prot:Q149L6

    Gene LinkOut

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