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    Narf nuclear prelamin A recognition factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360681, updated on 2-May-2024

    Summary

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    Symbol
    Narfprovided by RGD
    Full Name
    nuclear prelamin A recognition factorprovided by RGD
    Primary source
    RGD:1310894
    See related
    Ensembl:ENSRNOG00000036664 AllianceGenome:RGD:1310894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310894
    Summary
    Predicted to enable lamin binding activity. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in lamin filament. Orthologous to human NARF (nuclear prelamin A recognition factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 273.4), Thymus (RPKM 191.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Narf in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (107017344..107035777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106519508..106537494)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110445765..110463735)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hexosaminidase D Neighboring gene cytochrome b-245 chaperone 1 Neighboring gene phosphoglycerate mutase 1, pseudogene 1 Neighboring gene uncharacterized LOC134480920 Neighboring gene forkhead box K2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prenylated prelamin A interacts with Narf, a novel nuclear protein. Barton RM, et al. J Biol Chem, 1999 Oct 15. PMID 10514485
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125093

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear prelamin A recognition factor
    Names
    IOP2
    iron-only hydrogenase-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039207.2 → NP_001034296.1  nuclear prelamin A recognition factor

      See identical proteins and their annotated locations for NP_001034296.1

      Status: VALIDATED

      Source sequence(s)
      BC090020, BC110050
      UniProtKB/Swiss-Prot
      Q2YDU6
      UniProtKB/TrEMBL
      A0A8I5ZR12
      Related
      ENSRNOP00000051803.3, ENSRNOT00000054920.3
      Conserved Domains (3) summary
      smart00902
      Location:398 → 446
      Fe_hyd_SSU; Iron hydrogenase small subunit
      COG4624
      Location:43 → 443
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:92 → 384
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      107017344..107035777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597416.3 → XP_017452905.1  nuclear prelamin A recognition factor isoform X2

      UniProtKB/TrEMBL
      A0A8L2QR57

    2. XM_006247899.5 → XP_006247961.1  nuclear prelamin A recognition factor isoform X1

      UniProtKB/TrEMBL
      A0A8L2QR57
      Conserved Domains (2) summary
      TIGR02512
      Location:39 → 422
      FeFe_hydrog_A; [FeFe] hydrogenase, group A
      pfam02906
      Location:129 → 412
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2YDU6.1 GenPept UniProtKB/Swiss-Prot:Q2YDU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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