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    Bud31 BUD31 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89819, updated on 2-May-2024

    Summary

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    Official Symbol
    Bud31provided by RGD
    Official Full Name
    BUD31 homologprovided by RGD
    Primary source
    RGD:621103
    See related
    Ensembl:ENSRNOG00000000989 AllianceGenome:RGD:621103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G10; Edg2; LPA1
    Summary
    Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in mRNA splicing, via spliceosome and positive regulation of androgen receptor activity. Predicted to be located in nucleus. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to colocalize with chromatin. Biomarker of schistosomiasis. Orthologous to human BUD31 (BUD31 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 375.6), Thymus (RPKM 370.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bud31 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14576602..14584132, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9462838..9470387, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11232963..11240449, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1 like 2 Neighboring gene ATP synthase membrane subunit f Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene pentatricopeptide repeat domain 1 Neighboring gene PDGFA associated protein 1 Neighboring gene actin related protein 2/3 complex, subunit 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and profiling of circulating antigens by screening with the sera from schistosomiasis japonica patients. Lu Y, et al. Parasit Vectors, 2012 Jun 11. PMID 22686541, Free PMC Article
    2. The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Hirata T, et al. Brain Res, 2007 Jan 26. PMID 17173873
    3. EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. Savitz SI, et al. Brain Res, 2006 Nov 6. PMID 17026968
    4. Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. Sautin YY, et al. J Hematother Stem Cell Res, 2002 Aug. PMID 12201952
    5. Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid. Stankoff B, et al. Mol Cell Neurosci, 2002 Jul. PMID 12139919

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein BUD31 homolog
    Names
    EDG-2
    maternal G10 transcript
    protein EDG-2
    protein G10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053556.2 → NP_446008.2  protein BUD31 homolog

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Related
      ENSRNOP00000001307.4, ENSRNOT00000001307.8
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      14576602..14584132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248889.4 → XP_006248951.1  protein BUD31 homolog isoform X1

      See identical proteins and their annotated locations for XP_006248951.1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    2. XM_006248887.4 → XP_006248949.1  protein BUD31 homolog isoform X1

      See identical proteins and their annotated locations for XP_006248949.1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    3. XM_039089844.2 → XP_038945772.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    4. XM_063271721.1 → XP_063127791.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5

    5. XM_063271724.1 → XP_063127794.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5

    6. XM_039089845.2 → XP_038945773.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    7. XM_039089846.2 → XP_038945774.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
      Conserved Domains (1) summary
      pfam01125
      Location:1 → 143
      G10; G10 protein

    8. XM_063271723.1 → XP_063127793.1  protein BUD31 homolog isoform X1

      UniProtKB/Swiss-Prot
      O70454, Q6PDW3
      UniProtKB/TrEMBL
      A6K1F5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70454.2 GenPept UniProtKB/Swiss-Prot:O70454

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