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    Mansc1 MANSC domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67729, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mansc1provided by MGI
    Official Full Name
    MANSC domain containing 1provided by MGI
    Primary source
    MGI:MGI:1914979
    See related
    Ensembl:ENSMUSG00000032718 AllianceGenome:MGI:1914979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130403P13Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human MANSC1 (MANSC domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 17.3), stomach adult (RPKM 8.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G1; 6 65.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134586170..134609451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134609207..134632488, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406J09 gene Neighboring gene STARR-seq mESC enhancer starr_17545 Neighboring gene BCL2 like 14 Neighboring gene low density lipoprotein receptor-related protein 6 Neighboring gene STARR-seq mESC enhancer starr_17546 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134565289-134565590 Neighboring gene STARR-positive B cell enhancer ABC_E9105 Neighboring gene BLOC-1 related complex subunit 5 Neighboring gene predicted gene, 57779 Neighboring gene STARR-seq mESC enhancer starr_17547 Neighboring gene dual specificity phosphatase 16 Neighboring gene predicted gene, 36328

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MANSC domain-containing protein 1
    NP_080621.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026345.4 → NP_080621.1  MANSC domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_080621.1

      Status: VALIDATED

      Source sequence(s)
      AK033557, BC039930
      Consensus CDS
      CCDS20637.1
      UniProtKB/Swiss-Prot
      Q80V71, Q9CR33
      UniProtKB/TrEMBL
      Q3TAH6
      Related
      ENSMUSP00000038346.4, ENSMUST00000047443.5
      Conserved Domains (2) summary
      smart00765
      Location:23 → 116
      MANEC; The MANEC domain, formerly called MANSC
      PHA03255
      Location:234 → 394
      PHA03255; BDLF3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134586170..134609451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR33.1 GenPept UniProtKB/Swiss-Prot:Q9CR33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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