Guk1 guanylate kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Guk1provided by RGD
Official Full Name: guanylate kinase 1provided by RGD
Primary source: RGD:1309638
See related: Ensembl:ENSRNOG00000002928 AllianceGenome:RGD:1309638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables guanylate kinase activity. Involved in several processes, including glycoprotein transport; nucleobase-containing small molecule metabolic process; and nucleotide phosphorylation. Located in cytosol. Orthologous to human GUK1 (guanylate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 210.0), Heart (RPKM 194.6) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44471075..44488332, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43971514..43988658, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45535617..45552455, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH129753 (e-PCR)
- UniSTS:213046

Guk1 (e-PCR), detects polymorphism
- UniSTS:506964

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables guanylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside monophosphate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GDP-mannose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dATP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGDP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: guanylate kinase

Names: ATP:GMP-phosphotransferase

NP_001013133.2

EC 2.7.4.8

XP_006246539.1

EC 2.7.4.8

XP_063125059.1

EC 2.7.4.8

XP_063125060.1

EC 2.7.4.8

XP_063125061.1

EC 2.7.4.8

XP_063125062.1

EC 2.7.4.8

XP_063125063.1

EC 2.7.4.8

XP_063125064.1

EC 2.7.4.8

XP_063125065.1

EC 2.7.4.8

XP_063125066.1

EC 2.7.4.8

XP_063125067.1

EC 2.7.4.8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.