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    Spry1 sprouty RTK signaling antagonist 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294981, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Spry1provided by RGD
    Official Full Name
    sprouty RTK signaling antagonist 1provided by RGD
    Primary source
    RGD:1309293
    See related
    Ensembl:ENSRNOG00000025371 AllianceGenome:RGD:1309293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in epithelial to mesenchymal transition involved in cardiac fibroblast development and positive regulation of apoptotic process. Located in cytosol. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 172.0), Kidney (RPKM 126.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spry1 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (122484995..122490008)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (120557256..120561917)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (124400689..124405331)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene AFG2 AAA ATPase homolog A Neighboring gene small nucleolar RNA SNORA51 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene translocon-associated protein subunit delta-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury. Alakoski T, et al. Basic Res Cardiol, 2019 Jan 11. PMID 30635790, Free PMC Article
    2. Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung. Hashimoto S, et al. Pathobiology, 2012. PMID 22236546, Free PMC Article
    3. Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation. Boros J, et al. Semin Cell Dev Biol, 2006 Dec. PMID 17141539, Free PMC Article
    4. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Thum T, et al. Nature, 2008 Dec 18. PMID 19043405
    5. miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. Brønnum H, et al. PLoS One, 2013. PMID 23441172, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings indicate that Spry1 is an important regulator of cardiomyocyte viability during ischemia-reperfusion injury
      Title: Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.
    2. The spatio-temporal expression of Decorin, Semaphorin6D, SPARC, Spry-1 and Tsukushi in developing prostate is described and observed similar mesenchymal expression patterns in rat and human.
      Title: Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer.
    3. A comparison the distribution of Sprouty-1 and Sprouty-2 proteins by immunohistochemistry in developing and adult rat lung.
      Title: Immunolocalization of sprouty-1 and sprouty-2 in developing rat lung.
    4. Expressed in the lens throughout embryogenesis, Spry1 becomes restricted to the lens epithelium, indicating that lens cell proliferation and fiber differentiation may be tightly regulated by this negative regulatory molecule.
      Title: Sef and Sprouty expression in the developing ocular lens: implications for regulating lens cell proliferation and differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bud elongation involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within organ induction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein sprouty homolog 1
    Names
    sprouty homolog 1, antagonist of FGF signaling

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395072.1 → NP_001382001.1  protein sprouty homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZQE3, B5DFH3
      Related
      ENSRNOP00000080595.1, ENSRNOT00000102538.1
      Conserved Domains (1) summary
      pfam05210
      Location:180 → 282
      Sprouty; Sprouty protein (Spry)

    2. NM_001395073.1 → NP_001382002.1  protein sprouty homolog 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZQE3, B5DFH3
      Related
      ENSRNOP00000055291.2, ENSRNOT00000058495.3
      Conserved Domains (1) summary
      pfam05210
      Location:180 → 282
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      122484995..122490008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281571.1 → XP_063137641.1  protein sprouty homolog 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106427.1: Suppressed sequence

      Description
      NM_001106427.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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