U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rps27l ribosomal protein S27-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681429, updated on 6-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rps27lprovided by RGD
    Official Full Name
    ribosomal protein S27-likeprovided by RGD
    Primary source
    RGD:1595396
    See related
    Ensembl:ENSRNOG00000050473 AllianceGenome:RGD:1595396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rps27l1
    Summary
    Predicted to enable RNA binding activity; cysteine-type endopeptidase activator activity involved in apoptotic process; and translation activator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in intracellular signal transduction; positive regulation of cellular protein metabolic process; and ribosomal small subunit assembly. Predicted to be located in nucleus. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human RPS27L (ribosomal protein S27 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 498.5), Muscle (RPKM 424.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rps27l in Genome Data Viewer
    Location:
    8q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76443658..76448593)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67562483..67567418)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72741155..72746090)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6A1, pseudogene 1 Neighboring gene uncharacterized LOC102554897 Neighboring gene lactamase, beta Neighboring gene uncharacterized LOC134480198 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ribosomal protein S27-like, a p53-inducible modulator of cell fate in response to genotoxic stress. Li J, et al. Cancer Res, 2007 Dec 1. PMID 18056458
    2. Ribosomal protein S27L is a direct p53 target that regulates apoptosis. He H, et al. Oncogene, 2007 Apr 26. PMID 17057733
    3. Evolutionarily distinct classes of S27 ribosomal proteins with differential mRNA expression in rat hypothalamus. Thomas EA, et al. J Neurochem, 2000 Jun. PMID 10820185
    4. Zinc finger-like motifs in rat ribosomal proteins S27 and S29. Chan YL, et al. Nucleic Acids Res, 1993 Feb 11. PMID 8441676, Free PMC Article
    5. HAfTs are novel lncRNA transcripts from aflatoxin exposure. Merrick BA, et al. PLoS One, 2018. PMID 29351317, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    small ribosomal subunit protein eS27-like
    Names
    40S ribosomal protein S27-like
    ribosomal protein S27
    ribosomal protein S27-like 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276477.1 → NP_001263406.1  small ribosomal subunit protein eS27-like

      See identical proteins and their annotated locations for NP_001263406.1

      Status: VALIDATED

      Source sequence(s)
      CB712651, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P24051
      UniProtKB/TrEMBL
      A0A8L2QXZ3, A6KEZ8
      Related
      ENSRNOP00000071243.1, ENSRNOT00000090977.2
      Conserved Domains (1) summary
      PLN00209
      Location:6 → 82
      PLN00209; ribosomal protein S27; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76443658..76448593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082149.2 → XP_038938077.1  small ribosomal subunit protein eS27-like isoform X2

      UniProtKB/Swiss-Prot
      P24051
      UniProtKB/TrEMBL
      A0A8L2QXZ3, A6KEZ8
      Conserved Domains (1) summary
      PLN00209
      Location:6 → 82
      PLN00209; ribosomal protein S27; Provisional

    2. XM_063266130.1 → XP_063122200.1  small ribosomal subunit protein eS27-like isoform X1

      UniProtKB/TrEMBL
      A0A8L2QXZ3

    3. XM_063266131.1 → XP_063122201.1  small ribosomal subunit protein eS27-like isoform X3

      UniProtKB/TrEMBL
      A0A8I6AWD8, A6J6K5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24051.3 GenPept UniProtKB/Swiss-Prot:P24051

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous