Cers4 ceramide synthase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cers4provided by RGD
Official Full Name: ceramide synthase 4provided by RGD
Primary source: RGD:1309303
See related: Ensembl:ENSRNOG00000001072 AllianceGenome:RGD:1309303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lass4
Summary: Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to act upstream of or within sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human CERS4 (ceramide synthase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 125.4), Brain (RPKM 95.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (7649610..7688066)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (2851784..2890244)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (4439750..4474759, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide synthase 4

Names: LAG1 homolog, ceramide synthase 4; LAG1 longevity assurance homolog 4; longevity assurance homolog 4

NP_001100587.1

EC 2.3.1.24

XP_006248866.1

EC 2.3.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107117.2 → NP_001100587.1 ceramide synthase 4

See identical proteins and their annotated locations for NP_001100587.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6KQ80, D3ZU86

Related

ENSRNOP00000001418.5, ENSRNOT00000001418.6

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 126

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

7649610..7688066

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006248804.5 → XP_006248866.1 ceramide synthase 4 isoform X1

See identical proteins and their annotated locations for XP_006248866.1

UniProtKB/TrEMBL

A6KQ80, D3ZU86

Conserved Domains (2) summary

smart00724
Location:131 → 332

TLC; TRAM, LAG1 and CLN8 homology domains

cd00086
Location:83 → 126

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.