Etv1 ETS variant transcription factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etv1provided by RGD
Official Full Name: ETS variant transcription factor 1provided by RGD
Primary source: RGD:1312007
See related: Ensembl:ENSRNOG00000006867 AllianceGenome:RGD:1312007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including axon guidance; mechanosensory behavior; and positive regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 239.6), Adrenal (RPKM 84.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (61316836..61408985)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (55590149..55681784)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (58467215..58558640)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A cardiomyocyte-autonomous, ETV1-dependent pathway that is responsible for specification of rapid conduction zones in the heart was identified and ETV1 is sufficient to promote a His-Purkinje system transcriptional and functional program upon ventricular myocytes.
Title: ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.
The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.
Title: Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.

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General gene information

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Markers

Etv1 (e-PCR), detects polymorphism
- UniSTS:164893

Etv1 (e-PCR), detects polymorphism
- UniSTS:526897

Etv1 (e-PCR), detects polymorphism
- UniSTS:547915

MARC_7327-7328:992008337:1 (e-PCR)
- UniSTS:231318

BF386238 (e-PCR)
- UniSTS:243634

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mechanosensory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ETS translocation variant 1

Names: ets variant gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108709.3 → NP_001102179.2 ETS translocation variant 1 isoform b

See identical proteins and their annotated locations for NP_001102179.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.

Source sequence(s)

BC168860, BQ195622, JAXUCZ010000006

UniProtKB/TrEMBL

B5DEZ2

Related

ENSRNOP00000059718.1, ENSRNOT00000065396.4

Conserved Domains (2) summary

smart00413
Location:311 → 395

ETS; erythroblast transformation specific domain

pfam04621
Location:1 → 310

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
NM_001163156.3 → NP_001156628.1 ETS translocation variant 1 isoform a

See identical proteins and their annotated locations for NP_001156628.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

BC168860, BQ195622, CB547717, CB718897, JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JTM3, B5DEZ2

Conserved Domains (2) summary

smart00413
Location:334 → 418

ETS; erythroblast transformation specific domain

pfam04621
Location:2 → 333

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

61316836..61408985

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262098.1 → XP_063118168.1 ETS translocation variant 1 isoform X2
XM_063262097.1 → XP_063118167.1 ETS translocation variant 1 isoform X2
XM_008764648.4 → XP_008762870.1 ETS translocation variant 1 isoform X4

See identical proteins and their annotated locations for XP_008762870.1

UniProtKB/TrEMBL

B5DEZ2

Conserved Domains (2) summary

smart00413
Location:311 → 395

ETS; erythroblast transformation specific domain

pfam04621
Location:1 → 310

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_063262096.1 → XP_063118166.1 ETS translocation variant 1 isoform X1
XM_008764647.3 → XP_008762869.1 ETS translocation variant 1 isoform X3

Conserved Domains (2) summary

smart00413
Location:324 → 408

ETS; erythroblast transformation specific domain

pfam04621
Location:28 → 323

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
XM_063262100.1 → XP_063118170.1 ETS translocation variant 1 isoform X6
XM_063262099.1 → XP_063118169.1 ETS translocation variant 1 isoform X5