Scrn1 secernin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Scrn1provided by RGD
Full Name: secernin 1provided by RGD
Primary source: RGD:1560999
See related: Ensembl:ENSRNOG00000009636 AllianceGenome:RGD:1560999
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in exocytosis and proteolysis. Predicted to be located in nuclear membrane. Orthologous to human SCRN1 (secernin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 361.7), Uterus (RPKM 45.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (84962450..85024577, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (83632125..83694225, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (84678978..84740701, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE095530 (e-PCR)
- UniSTS:243471

D4Got63 (e-PCR)
- UniSTS:112296

AU048678 (e-PCR)
- UniSTS:145128

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: secernin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025063.1 → NP_001020234.1 secernin-1

See identical proteins and their annotated locations for NP_001020234.1

Status: PROVISIONAL

Source sequence(s)

BC079152

UniProtKB/Swiss-Prot

Q6AY84

UniProtKB/TrEMBL

A6K0V2

Conserved Domains (1) summary

cl00467
Location:18 → 227

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

84962450..85024577 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108254.2 → XP_038964182.1 secernin-1 isoform X1

UniProtKB/Swiss-Prot

Q6AY84

UniProtKB/TrEMBL

A6K0V2

Related

ENSRNOP00000013088.3

Conserved Domains (1) summary

cl00467
Location:18 → 227

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
XM_006236512.5 → XP_006236574.1 secernin-1 isoform X1

See identical proteins and their annotated locations for XP_006236574.1

UniProtKB/Swiss-Prot

Q6AY84

UniProtKB/TrEMBL

A6K0V2

Conserved Domains (1) summary

cl00467
Location:18 → 227

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
XM_063286615.1 → XP_063142685.1 secernin-1 isoform X2