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    Zdhhc14 zinc finger DHHC-type palmitoyltransferase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499014, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zdhhc14provided by RGD
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 14provided by RGD
    Primary source
    RGD:1565877
    See related
    Ensembl:ENSRNOG00000029049 AllianceGenome:RGD:1565877
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dhhc14
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC14 (zinc finger DHHC-type palmitoyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 40.4), Brain (RPKM 39.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zdhhc14 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (48473860..48746201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46069127..46340806)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (46378807..46658527)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 242 Neighboring gene lactate dehydrogenase A-like 6B Neighboring gene uncharacterized LOC120099115 Neighboring gene uncharacterized LOC134484994 Neighboring gene sorting nexin 9 Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article
    2. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno Y, et al. Biochim Biophys Acta, 2006 Apr. PMID 16647879
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC14
    Names
    membrane-associated DHHC14 zinc finger protein
    probable palmitoyltransferase ZDHHC14
    zinc finger, DHHC domain containing 14
    zinc finger, DHHC-type containing 14
    NP_001034432.1
    XP_006227946.1
    XP_006227947.1
    XP_006227948.1
    XP_038942732.1
    XP_038942735.1
    XP_038942743.1
    XP_063126719.1
    XP_063126723.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039343.1 → NP_001034432.1  palmitoyltransferase ZDHHC14

      See identical proteins and their annotated locations for NP_001034432.1

      Status: PROVISIONAL

      Source sequence(s)
      AY886530
      UniProtKB/TrEMBL
      D3ZZI1, Q2TGJ5
      Related
      ENSRNOP00000051330.4, ENSRNOT00000043521.5
      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      48473860..48746201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227886.5 → XP_006227948.1  palmitoyltransferase ZDHHC14 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_063270653.1 → XP_063126723.1  palmitoyltransferase ZDHHC14 isoform X5

    3. XM_006227885.5 → XP_006227947.1  palmitoyltransferase ZDHHC14 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_006227884.5 → XP_006227946.1  palmitoyltransferase ZDHHC14 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:314 → 471
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    5. XM_039086804.2 → XP_038942732.1  palmitoyltransferase ZDHHC14 isoform X6

      Conserved Domains (1) summary
      PHA03247
      Location:103 → 275
      PHA03247; large tegument protein UL36; Provisional

    6. XM_039086807.2 → XP_038942735.1  palmitoyltransferase ZDHHC14 isoform X6

      Conserved Domains (1) summary
      PHA03247
      Location:103 → 275
      PHA03247; large tegument protein UL36; Provisional

    7. XM_063270649.1 → XP_063126719.1  palmitoyltransferase ZDHHC14 isoform X4

      UniProtKB/TrEMBL
      A6KNZ0

    8. XM_039086815.2 → XP_038942743.1  palmitoyltransferase ZDHHC14 isoform X7

    RNA

    1. XR_349967.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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