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    Rpl22 ribosomal protein L22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81768, updated on 2-May-2024

    Summary

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    Official Symbol
    Rpl22provided by RGD
    Official Full Name
    ribosomal protein L22provided by RGD
    Primary source
    RGD:621189
    See related
    Ensembl:ENSRNOG00000069581 AllianceGenome:RGD:621189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including heparin binding activity; identical protein binding activity; and translation regulator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and regulation of translation at presynapse, modulating synaptic transmission. Predicted to act upstream of or within alpha-beta T cell differentiation. Located in ribosome. Part of cytosolic large ribosomal subunit. Orthologous to human RPL22 (ribosomal protein L22). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 1727.5), Thymus (RPKM 1527.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl22 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168114432..168126114)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162835241..162843394)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169506150..169512875)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene ring finger protein 207 Neighboring gene uncharacterized LOC120103139 Neighboring gene chromodomain helicase DNA binding protein 5 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2 Neighboring gene small ribosomal subunit protein eS27-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The primary structure of rat ribosomal protein L22. Chan YL, et al. Biochim Biophys Acta, 1995 Jan 2. PMID 7999786
    2. Dynamic Axonal Translation in Developing and Mature Visual Circuits. Shigeoka T, et al. Cell, 2016 Jun 30. PMID 27321671, Free PMC Article
    3. The primary structure of rat ribosomal protein L24. Chan YL, et al. Biochem Biophys Res Commun, 1994 Jul 29. PMID 8048931
    4. Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. Anderson SJ, et al. Immunity, 2007 Jun. PMID 17555992
    5. A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Fujita Y, et al. Biochem Biophys Res Commun, 1994 Mar 15. PMID 8135813

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL22
    Names
    60S ribosomal protein L22
    NP_112366.2
    XP_063144543.1
    XP_063144544.1
    XP_063144545.1
    XP_063144546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031104.2 → NP_112366.2  large ribosomal subunit protein eL22

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I5Y921, A6IUI2, F7FLF2, Q6PDV8
      Related
      ENSRNOP00000076672.1, ENSRNOT00000104092.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168114432..168126114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288475.1 → XP_063144545.1  large ribosomal subunit protein eL22 isoform X3

    2. XM_063288474.1 → XP_063144544.1  large ribosomal subunit protein eL22 isoform X2

    3. XM_063288473.1 → XP_063144543.1  large ribosomal subunit protein eL22 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZF1

    4. XM_063288476.1 → XP_063144546.1  large ribosomal subunit protein eL22 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AMR8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47198.2 GenPept UniProtKB/Swiss-Prot:P47198

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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