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    Oas2 2'-5' oligoadenylate synthetase 2 [ Mus musculus (house mouse) ]

    Gene ID: 246728, updated on 19-Mar-2024

    Summary

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    Official Symbol
    Oas2provided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase 2provided by MGI
    Primary source
    MGI:MGI:2180852
    See related
    Ensembl:ENSMUSG00000032690 AllianceGenome:MGI:2180852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oasl11
    Summary
    Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in defense response to virus; regulation of lactation; and type I interferon signaling pathway. Acts upstream of or within RNA catabolic process; interleukin-27-mediated signaling pathway; and response to bacterium. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleoplasm. Is expressed in embryo. Orthologous to human OAS2 (2'-5'-oligoadenylate synthetase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 7.4), mammary gland adult (RPKM 7.0) and 20 other tissues See more
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    Genomic context

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    Location:
    5 F; 5 60.64 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120868398..120887949, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120730333..120749886, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4782 Neighboring gene RAS protein activator like 1 (GAP1 like) Neighboring gene STARR-positive B cell enhancer ABC_E11300 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121135771-121135981 Neighboring gene deltex 1, E3 ubiquitin ligase Neighboring gene STARR-positive B cell enhancer ABC_E8075 Neighboring gene STARR-positive B cell enhancer ABC_E6371 Neighboring gene STARR-seq mESC enhancer starr_14247 Neighboring gene STARR-seq mESC enhancer starr_14249 Neighboring gene 2'-5' oligoadenylate synthetase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225553-121225736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:121225792-121225979 Neighboring gene 2'-5' oligoadenylate synthetase 1E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation. Oakes SR, et al. PLoS Genet, 2017 Nov. PMID 29117179, Free PMC Article
    2. Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity. Sarkar SN, et al. Biochemistry, 2005 May 10. PMID 15865429
    3. IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. Kwock JT, et al. Sci Adv, 2020 Apr. PMID 32270034, Free PMC Article
    4. Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases. Mashimo T, et al. Genomics, 2003 Nov. PMID 14559211
    5. Gene structure of the murine 2'-5'-oligoadenylate synthetase family. Eskildsen S, et al. Cell Mol Life Sci, 2002 Jul. PMID 12222967

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2'-5'-oligoadenylate synthetase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in interleukin-27-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lactation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to virus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    2'-5'-oligoadenylate synthase 2
    Names
    (2-5')oligo(A) synthase 2
    2',5'-oligoadenylate synthetase-like 11
    2,5-oligoadenylate synthetase-like 11
    2-5A synthase 2
    NP_001334377.1
    NP_660262.2
    XP_036021033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347448.1 → NP_001334377.1  2'-5'-oligoadenylate synthase 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC115937
      Consensus CDS
      CCDS84949.1
      UniProtKB/Swiss-Prot
      E9Q9A9
      Related
      ENSMUSP00000080209.7, ENSMUST00000081491.13

    2. NM_145227.3 → NP_660262.2  2'-5'-oligoadenylate synthase 2 isoform 2

      See identical proteins and their annotated locations for NP_660262.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB067535, BC118538, BU694306
      Consensus CDS
      CCDS19625.2
      UniProtKB/Swiss-Prot
      E9Q9A9, Q8K4E5, Q8VI92
      Related
      ENSMUSP00000060082.7, ENSMUST00000053909.13
      Conserved Domains (2) summary
      cd05400
      Location:401 → 583
      NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
      pfam10421
      Location:538 → 721
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      120868398..120887949 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165140.1 → XP_036021033.1  2'-5'-oligoadenylate synthase 2 isoform X1

    RNA

    1. XR_387564.4 RNA Sequence

    2. XR_004942516.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q9A9.1 GenPept UniProtKB/Swiss-Prot:E9Q9A9

    Gene LinkOut

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