Hopx HOP homeobox [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hopxprovided by MGI
Official Full Name: HOP homeoboxprovided by MGI
Primary source: MGI:MGI:1916782
See related: Ensembl:ENSMUSG00000059325 AllianceGenome:MGI:1916782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hod; Hop; Ob1; Obl; Hdop; Toto; Cameo; 1110018K11Rik; 1200015P04Rik; 2300002F06Rik
Summary: Predicted to enable DNA binding activity. Acts upstream of or within several processes, including lung alveolus development; positive regulation of skeletal muscle tissue regeneration; and trophectodermal cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; heart; nose; trophectoderm; and urinary system. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 209.4), heart adult (RPKM 74.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 41.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (77234831..77262970, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (77086986..77115123, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice.
Title: Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice.
HOPX expression in cultured ATII cells increased over culture time. HOPX expression was increased in AECs from bleomycin-instilled mouse lungs in vivo. Small interfering RNA-based knockdown of Hopx resulted in suppressing ATII-ATI trans-differentiation and activating cellular proliferation in vitro.
Title: Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis.
These results support an early priming of neural stem cells (NSCs) for the genesis of defined cell types depending on their spatial location in the subventricular zone and identify HOPX as a marker of a subpopulation primed toward astrocytic fates.
Title: HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells.
Hopx is required and sufficient, respectively, for basal radial glial cells abundance as found in the developing gyrencephalic neocortex.
Title: A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex.
Analysis of the hematopoietic stem/progenitor cell pool in Hopx-/- mice demonstrated significantly reduced cell frequencies and impaired engraftment in competitive repopulation assays, thus providing functional validation of this positional candidate gene
Title: The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice.
Type I alveolar cells expressing Hopx manifest plasticity to regenerate type II alveolar cells in the lung.
Title: Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression.
Title: Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells That Require Hopx To Inhibit Intrinsic IL-2 Expression.
Hopx integrates Bmp and Wnt signaling by physically interacting with activated Smads and repressing Wnt genes.
Title: HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.
Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
Title: Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure.
Title: Homeodomain only protein x is down-regulated in human heart failure.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Mit357 (e-PCR), detects polymorphism
- UniSTS:130510

AW490897 (e-PCR)
- UniSTS:179181

AI848177 (e-PCR)
- UniSTS:179183

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gap junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trophectodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: homeodomain-only protein

Names: homeobox only domain; homeobox-only protein; mOB1; odd homeobox 1; odd homeobox protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159900.1 → NP_001153372.1 homeodomain-only protein

See identical proteins and their annotated locations for NP_001153372.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AK003784, BB598275, BM123896, CO044889

Consensus CDS

CCDS39120.1

UniProtKB/Swiss-Prot

Q8C1N5, Q8CJ22, Q8R1H0

Related

ENSMUSP00000109080.3, ENSMUST00000113453.9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001159901.1 → NP_001153373.1 homeodomain-only protein

See identical proteins and their annotated locations for NP_001153373.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AI604115, AK009007, BB598275, BE956264, BM123896

Consensus CDS

CCDS39120.1

UniProtKB/Swiss-Prot

Q8C1N5, Q8CJ22, Q8R1H0

Related

ENSMUSP00000113295.3, ENSMUST00000120827.9

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_175606.3 → NP_783199.1 homeodomain-only protein

See identical proteins and their annotated locations for NP_783199.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AF534182, AK009007, BE956264, BM123896

Consensus CDS

CCDS39120.1

UniProtKB/Swiss-Prot

Q8C1N5, Q8CJ22, Q8R1H0

Related

ENSMUSP00000080630.5, ENSMUST00000081964.7

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

77234831..77262970 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165564.1 → XP_036021457.1 homeodomain-only protein isoform X1

UniProtKB/Swiss-Prot

Q8C1N5, Q8CJ22, Q8R1H0

Conserved Domains (1) summary

cd00086
Location:10 → 62

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.