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    Scn7a sodium channel, voltage-gated, type VII, alpha [ Mus musculus (house mouse) ]

    Gene ID: 20272, updated on 16-Oct-2021

    Summary

    Official Symbol
    Scn7aprovided by MGI
    Official Full Name
    sodium channel, voltage-gated, type VII, alphaprovided by MGI
    Primary source
    MGI:MGI:102965
    See related
    Ensembl:ENSMUSG00000034810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NaG; Nax; Nav2; Scn6a; Nav2.3; AI642000; 1110034K09Rik
    Expression
    Biased expression in lung adult (RPKM 20.0), bladder adult (RPKM 6.6) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Scn7a in Genome Data Viewer
    Location:
    2 C1.3; 2 39.21 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (66503770..66615254, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (66673426..66784910, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (66511483..66622967, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35, pseudogene 1 Neighboring gene predicted gene 13629 Neighboring gene sodium channel, voltage-gated, type IX, alpha Neighboring gene predicted gene, 35265 Neighboring gene predicted gene 13600 Neighboring gene eukaryotic translation initiation factor 2 subunit 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium channel protein type 7 subunit alpha
    Names
    sodium channel, voltage-gated, type VI, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009135.2NP_033161.2  sodium channel protein type 7 subunit alpha

      Status: VALIDATED

      Source sequence(s)
      AL928623, AL928720
      Consensus CDS
      CCDS16081.1
      UniProtKB/TrEMBL
      B1AYL1, Q62467
      Related
      ENSMUSP00000042405.7, ENSMUST00000042792.7
      Conserved Domains (3) summary
      cd13433
      Location:11951246
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:9511204
      Ion_trans; Ion transport protein
      pfam06512
      Location:743927
      Na_trans_assoc; Sodium ion transport-associated

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      66503770..66615254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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