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    Hacd2 3-hydroxyacyl-CoA dehydratase 2 [ Mus musculus (house mouse) ]

    Gene ID: 70757, updated on 12-May-2024

    Summary

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    Official Symbol
    Hacd2provided by MGI
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 2provided by MGI
    Primary source
    MGI:MGI:1918007
    See related
    Ensembl:ENSMUSG00000035376 AllianceGenome:MGI:1918007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hcad2; Ptplb; 6330408J20Rik
    Summary
    Predicted to enable 3-hydroxyacyl-CoA dehydratase activity; 3R-hydroxyacyl-CoA dehydratase activity; and enzyme binding activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 24.6), subcutaneous fat pad adult (RPKM 18.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hacd2 in Genome Data Viewer
    Location:
    16 B3; 16 24.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (34842791..34929560)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35022421..35109190)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide kinase Neighboring gene RIKEN cDNA E130310I04 gene Neighboring gene STARR-seq mESC enhancer starr_40730 Neighboring gene STARR-seq mESC enhancer starr_40731 Neighboring gene STARR-positive B cell enhancer ABC_E1922 Neighboring gene predicted gene, 21691 Neighboring gene predicted gene, 53952 Neighboring gene STARR-seq mESC enhancer starr_40734 Neighboring gene adenylate cyclase 5 Neighboring gene STARR-seq mESC enhancer starr_40735 Neighboring gene predicted gene, 46550 Neighboring gene STARR-seq mESC enhancer starr_40736 Neighboring gene predicted gene, 25179 Neighboring gene STARR-seq mESC enhancer starr_40737 Neighboring gene SEC22 homolog A, vesicle trafficking protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. Uwanogho DA, et al. Genomics, 1999 Dec 15. PMID 10644438
    2. HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth. Blondelle J, et al. J Mol Cell Biol, 2015 Oct. PMID 26160855, Free PMC Article
    3. Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease. Khadhraoui N, et al. Mol Metab, 2023 Mar. PMID 36693621, Free PMC Article
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.
      Title: Hacd2 deficiency in mice leads to an early and lethal mitochondrial disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2
    Names
    protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
    protein-tyrosine phosphatase-like member B
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2
    NP_076076.2
    XP_006522633.1
    XP_006522634.1
    XP_036016022.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023587.2 → NP_076076.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2

      See identical proteins and their annotated locations for NP_076076.2

      Status: VALIDATED

      Source sequence(s)
      AC154230, AK148143
      Consensus CDS
      CCDS37321.1
      UniProtKB/Swiss-Prot
      Q3UG38, Q9D3B1, Q9JLK1
      Related
      ENSMUSP00000060462.9, ENSMUST00000061156.10
      Conserved Domains (1) summary
      pfam04387
      Location:85 → 244
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      34842791..34929560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160129.1 → XP_036016022.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

      Conserved Domains (1) summary
      pfam04387
      Location:1 → 134
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    2. XM_006522570.4 → XP_006522633.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

      See identical proteins and their annotated locations for XP_006522633.1

      Conserved Domains (1) summary
      pfam04387
      Location:1 → 134
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    3. XM_006522571.1 → XP_006522634.1  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 isoform X1

      See identical proteins and their annotated locations for XP_006522634.1

      Conserved Domains (1) summary
      pfam04387
      Location:1 → 134
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3B1.1 GenPept UniProtKB/Swiss-Prot:Q9D3B1

    Gene LinkOut

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