Rint1 RAD50 interactor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rint1provided by MGI
Official Full Name: RAD50 interactor 1provided by MGI
Primary source: MGI:MGI:1916233
See related: Ensembl:ENSMUSG00000028999 AllianceGenome:MGI:1916233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rint-1; 1500019C06Rik; 2810450M21Rik
Summary: Predicted to be involved in mitotic G2 DNA damage checkpoint signaling; regulation of ER to Golgi vesicle-mediated transport; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 6.8), limb E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 10.45 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (23992700..24028582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (23787698..23823584)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RINT1 has a role as a multitasking protein with roles in genomic stability, ER homeostasis, and autophagy
Title: RINT1 functions as a multitasking protein at the crossroads between genomic stability, ER homeostasis, and autophagy.
these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer.
Title: Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.
A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy.
Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
Title: RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of ER to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ER to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Dsl1/NZR complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RAD50-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310467.1 → NP_001297396.1 RAD50-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001297396.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK005284, AK028707, BC065059

Consensus CDS

CCDS80220.1

UniProtKB/TrEMBL

B2RWX4

Related

ENSMUSP00000110766.3, ENSMUST00000115113.3

Conserved Domains (1) summary

pfam04437
Location:246 → 726

RINT1_TIP1; RINT-1 / TIP-1 family
NM_177323.4 → NP_796297.2 RAD50-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_796297.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK005284, AK135334, BC065059

Consensus CDS

CCDS39025.1

UniProtKB/Swiss-Prot

Q3UXS1, Q6P1I2, Q8BZ36, Q8C193

UniProtKB/TrEMBL

B2RWX4

Related

ENSMUSP00000030852.7, ENSMUST00000030852.13

Conserved Domains (1) summary

pfam04437
Location:304 → 784

RINT1_TIP1; RINT-1 / TIP-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

23992700..24028582

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165534.1 → XP_036021427.1 RAD50-interacting protein 1 isoform X1

UniProtKB/TrEMBL

B2RWX4

Conserved Domains (1) summary

pfam04437
Location:168 → 648

RINT1_TIP1; RINT-1 / TIP-1 family