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    Cyp9f2 Cytochrome P450 9f2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41520, updated on 10-May-2024

    Summary

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    Official Symbol
    Cyp9f2provided by FlyBase
    Official Full Name
    Cytochrome P450 9f2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038037
    Locus tag
    Dmel_CG11466
    See related
    AllianceGenome:FB:FBgn0038037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9f2; anon-EST:Posey150; CG11466; Cyp 9f2; Cyp9F2; CYP9F2; Dmel\CG11466
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Involved in wing disc development. Is expressed in adult head; adult heart; embryonic/larval midgut; epithelium; and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; essential hypertension; familial Mediterranean fever; leukemia (multiple); and platelet-type bleeding disorder 14. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cyp9f2 in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12403340..12406028, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8229062..8231750, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sol1 Neighboring gene Cytochrome P450 9f3 Neighboring gene DNA ligase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dibutyl Phthalate Exposure Disrupts Evolutionarily Conserved Insulin and Glucagon-Like Signaling in Drosophila Males. Williams MJ, et al. Endocrinology, 2016 Jun. PMID 27100621
    2. RNA interference validation of detoxification genes involved in ivermectin tolerance in Drosophila melanogaster. Kim JH, et al. Insect Mol Biol, 2018 Oct. PMID 29888824
    3. Short exposure to nitenpyram pesticide induces effects on reproduction, development and metabolic gene expression profiles in Drosophila melanogaster (Diptera: Drosophilidae). Ahmed MAI, et al. Sci Total Environ, 2022 Jan 15. PMID 34798758, Free PMC Article
    4. Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster. Ahmed MAI, et al. Chemosphere, 2020 Aug. PMID 32283422, Free PMC Article
    5. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 9f2
    Names
    CG11466-PA
    Cyp9f2-PA
    cytochrome P450
    NP_650189.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12403340..12406028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141932.3 → NP_650189.1  cytochrome P450 9f2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VG82
      Related
      FBpp0082070
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 510
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG82.1 Q9VG82

    Gene LinkOut

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