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    Men-b Malic enzyme b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43936, updated on 10-May-2024

    Summary

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    Official Symbol
    Men-bprovided by FlyBase
    Official Full Name
    Malic enzyme bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029155
    Locus tag
    Dmel_CG5889
    See related
    AllianceGenome:FB:FBgn0029155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey79; CG5889; dME-3; dME3; Dmel\CG5889; Mdh; MDH; Men-B
    Summary
    Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in glucose homeostasis. Predicted to be active in mitochondrion. Is expressed in several structures, including circulatory system; embryonic brain; embryonic/larval digestive system; embryonic/larval nervous system; and eye disc. Orthologous to several human genes including ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Men-b in Genome Data Viewer
    Location:
    97E5-97E5; 3-92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27151662..27157603)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22977384..22983325)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gram-positive Specific Serine protease Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae. George J, et al. Fly (Austin), 2019 Mar-Dec. PMID 31526131, Free PMC Article
    2. The genetic structure of the Raleigh natural population of Drosophila melanogaster revisited. Kusakabe S, et al. Genetics, 2000 Feb. PMID 10655221, Free PMC Article
    3. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Bradshaw PC. Nutrients, 2019 Feb 27. PMID 30818813, Free PMC Article
    4. Drosophila sperm development and intercellular cytoplasm sharing through ring canals do not require an intact fusome. Kaufman RS, et al. Development, 2020 Nov 15. PMID 33033119, Free PMC Article
    5. Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage. Arking R, et al. Exp Gerontol, 2000 May. PMID 10832056

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables malic enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    malic enzyme b
    Names
    CG5889-PA
    CG5889-PB
    CG5889-PC
    Mdh
    Men-b-PA
    Men-b-PB
    Men-b-PC
    malic DH
    NP_001163749.1
    NP_001163750.1
    NP_651959.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27151662..27157603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170279.2 → NP_001163750.1  malic enzyme b, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIZ4, Q9U1J0
      Conserved Domains (3) summary
      cd05312
      Location:308 → 585
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:51 → 590
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:117 → 298
      malic; Malic enzyme, N-terminal domain

    2. NM_143702.4 → NP_651959.1  malic enzyme b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1J0, Q9VB69
      Related
      FBpp0084480
      Conserved Domains (3) summary
      cd05312
      Location:308 → 585
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:51 → 590
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:117 → 298
      malic; Malic enzyme, N-terminal domain

    3. NM_001170278.2 → NP_001163749.1  malic enzyme b, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIZ5, Q9U1J0
      Conserved Domains (3) summary
      cd05312
      Location:308 → 585
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:51 → 590
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:117 → 298
      malic; Malic enzyme, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIZ4 E1JIZ4
    E1JIZ5 E1JIZ5
    Q9U1J0 Q9U1J0
    Q9VB69 Q9VB69

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