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    UGP UDP-glucose pyrophosphorylase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39065, updated on 10-May-2024

    Summary

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    Official Symbol
    UGPprovided by FlyBase
    Official Full Name
    UDP-glucose pyrophosphorylaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035978
    Locus tag
    Dmel_CG4347
    See related
    AllianceGenome:FB:FBgn0035978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4347; Dmel\CG4347; dUGP; UDPGPP; UGPase
    Summary
    Predicted to enable UTP:glucose-1-phosphate uridylyltransferase activity. Involved in response to hyperoxia. Located in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval muscle system; extended germ band embryo; and germline cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See UGP in Genome Data Viewer
    Location:
    67B1-67B2; 3-29 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9350867..9358935, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9343967..9352035, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peptidoglycan recognition protein LA Neighboring gene Peptidoglycan recognition protein LC Neighboring gene Peptidoglycan recognition protein LF Neighboring gene uncharacterized protein Neighboring gene small VCP interacting protein Neighboring gene Pyridoxal kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Jumbo-Lucioni PP, et al. Hum Mol Genet, 2016 Sep 1. PMID 27466186, Free PMC Article
    2. Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Zhao HW, et al. Placenta, 2011 Mar. PMID 21353099, Free PMC Article
    3. The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage. Ruaud AF, et al. Mol Endocrinol, 2011 Jan. PMID 21084378, Free PMC Article
    4. Glycogen branching enzyme controls cellular iron homeostasis via Iron Regulatory Protein 1 and mitoNEET. Huynh N, et al. Nat Commun, 2019 Nov 29. PMID 31784520, Free PMC Article
    5. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Terhzaz S, et al. J Biol Chem, 2006 Jul 7. PMID 16670086

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UTP:glucose-1-phosphate uridylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucose pyrophosphorylase
    Names
    CG4347-PA
    CG4347-PC
    CG4347-PD
    CG4347-PE
    UGP-PA
    UGP-PC
    UGP-PD
    UGP-PE
    UTP-G-1-P uridyiyltransferase
    uridine diphosphate-glucose pyrophosphorylase
    NP_001163399.1
    NP_001163400.1
    NP_648300.3
    NP_729469.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9350867..9358935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169929.2 → NP_001163400.1  UDP-glucose pyrophosphorylase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JI91, E8NH18
      Conserved Domains (1) summary
      pfam01704
      Location:68 → 483
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    2. NM_140043.5 → NP_648300.3  UDP-glucose pyrophosphorylase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648300.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH18, Q8T0B8, Q9VSW1
      Conserved Domains (1) summary
      pfam01704
      Location:68 → 485
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    3. NM_001169928.2 → NP_001163399.1  UDP-glucose pyrophosphorylase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5XCL5, E8NH18
      Conserved Domains (1) summary
      pfam01704
      Location:61 → 476
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    4. NM_168325.4 → NP_729469.2  UDP-glucose pyrophosphorylase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH18, Q86NQ8, Q9VSW2
      Conserved Domains (1) summary
      pfam01704
      Location:61 → 478
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5XCL5 A5XCL5
    E1JI91 E1JI91
    Q8SXQ2 Q8SXQ2
    Q9VSW1 Q9VSW1
    Q9VSW2 Q9VSW2

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