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    Fer1HCH Ferritin 1 heavy chain homologue [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 46415, updated on 10-May-2024

    Summary

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    Official Symbol
    Fer1HCHprovided by FlyBase
    Official Full Name
    Ferritin 1 heavy chain homologueprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015222
    Locus tag
    Dmel_CG2216
    See related
    AllianceGenome:FB:FBgn0015222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1HCH; BEST:LD36673; CG2216; Dmel\CG2216; Fe1HCH; Fer-L; fer1; Fer1; FER1; Fer1H; Fer1HC; fer1hch; fer1HCH; FER1HCH; FerHCH; HCH; l(3)00451; l(3)j10B4; T21; T9
    Summary
    Enables ferrous iron binding activity. Involved in detoxification of iron ion and iron ion import across plasma membrane. Located in Golgi apparatus and fusome. Part of intracellular ferritin complex. Is expressed in several structures, including circulatory system; extended germ band embryo; gonad; gut; and head. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Fer1HCH in Genome Data Viewer
    Location:
    99F2-99F2; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30385573..30388178, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26211295..26213900, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene headcase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46114 Neighboring gene Ferritin 2 light chain homologue Neighboring gene long non-coding RNA:CR45570 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ferritin accumulation under iron scarcity in Drosophila iron cells. Mehta A, et al. Biochimie, 2009 Oct. PMID 19465081
    2. Genetic screening for novel Drosophila mutants with discrepancies in iron metabolism. Mehta A, et al. Biochem Soc Trans, 2008 Dec. PMID 19021547
    3. Drosophila ferritin mRNA: alternative RNA splicing regulates the presence of the iron-responsive element. Lind MI, et al. FEBS Lett, 1998 Oct 9. PMID 9801172
    4. Ferritin Assembly in Enterocytes of Drosophila melanogaster. Rosas-Arellano A, et al. Int J Mol Sci, 2016 Feb 5. PMID 26861293, Free PMC Article
    5. Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Kosmidis S, et al. Front Pharmacol, 2014. PMID 24772084, Free PMC Article

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data present analyses of embryonic phenotypes for mutations in ferritin Fer1HCH, Fer2LCH and in both genes simultaneously.
      Title: Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development.
    2. Expression of ferritin subunits in glial cells of Drosophila melanogaster causes a late-onset behavioral decline, characterized by loss of circadian rhythms in constant darkness and impairment of elicited locomotor responses.
      Title: Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects.
    3. Mitoferrin overexpression upregulated Fer1HCH transcription.
      Title: Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferroxidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular sequestering of iron ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to fungus HEP PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intracellular ferritin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferritin 1 heavy chain homologue
    Names
    CG2216-PA
    CG2216-PB
    CG2216-PC
    CG2216-PD
    CG2216-PE
    CG2216-PF
    CG2216-PG
    CG2216-PI
    CG2216-PJ
    Fer1HCH-PA
    Fer1HCH-PB
    Fer1HCH-PC
    Fer1HCH-PD
    Fer1HCH-PE
    Fer1HCH-PF
    Fer1HCH-PG
    Fer1HCH-PI
    Fer1HCH-PJ
    Ferritin-Heavy
    Ferritin-Light
    Ferritin1
    ferritin
    ferritin 1 heavy chain
    ferritin 1 heavy chain homolog
    ferritin 1HCH
    ferritin H
    ferritin HCH
    ferritin heavy chain
    ferritin subunit 1
    ferritin-1 heavy chain homolog
    NP_001247366.1
    NP_001247367.1
    NP_001263104.1
    NP_001287608.1
    NP_524873.1
    NP_733358.1
    NP_733359.1
    NP_733360.1
    NP_733361.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30385573..30388178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080134.4 → NP_524873.1  ferritin 1 heavy chain homologue, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524873.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
      UniProtKB/TrEMBL
      B9EQV2
      Related
      FBpp0084995
      Conserved Domains (2) summary
      cd01056
      Location:39 → 203
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 → 189
      Ferritin; Ferritin-like domain

    2. NM_170479.3 → NP_733358.1  ferritin 1 heavy chain homologue, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
      UniProtKB/TrEMBL
      B9EQV2
      Related
      FBpp0084996
      Conserved Domains (2) summary
      cd01056
      Location:39 → 203
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 → 189
      Ferritin; Ferritin-like domain

    3. NM_170482.3 → NP_733361.1  ferritin 1 heavy chain homologue, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733361.1

      Status: REVIEWED

      Related
      FBpp0084999
      Conserved Domains (2) summary
      pfam00210
      Location:42 → 102
      Ferritin; Ferritin-like domain
      cl00264
      Location:39 → 102
      Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

    4. NM_001260438.2 → NP_001247367.1  ferritin 1 heavy chain homologue, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A405, B9EQV2
      Conserved Domains (2) summary
      cd01056
      Location:76 → 240
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:79 → 226
      Ferritin; Ferritin-like domain

    5. NM_170481.3 → NP_733360.1  ferritin 1 heavy chain homologue, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733360.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
      UniProtKB/TrEMBL
      B9EQV2
      Related
      FBpp0084998
      Conserved Domains (2) summary
      cd01056
      Location:39 → 203
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 → 189
      Ferritin; Ferritin-like domain

    6. NM_170480.3 → NP_733359.1  ferritin 1 heavy chain homologue, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H1UUD2, Q7KMQ5, Q7KRU8, Q8I0T0
      UniProtKB/TrEMBL
      B9EQV2
      Related
      FBpp0084997
      Conserved Domains (2) summary
      cd01056
      Location:39 → 203
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:42 → 189
      Ferritin; Ferritin-like domain

    7. NM_001276175.2 → NP_001263104.1  ferritin 1 heavy chain homologue, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI27, B9EQV2
      Conserved Domains (2) summary
      cd01056
      Location:79 → 243
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:82 → 229
      Ferritin; Ferritin-like domain

    8. NM_001300679.1 → NP_001287608.1  ferritin 1 heavy chain homologue, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287608.1

      Status: REVIEWED

      Conserved Domains (2) summary
      cd01056
      Location:3 → 167
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:6 → 153
      Ferritin; Ferritin-like domain

    9. NM_001260437.1 → NP_001247366.1  ferritin 1 heavy chain homologue, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A405, B9EQV2
      Conserved Domains (2) summary
      cd01056
      Location:76 → 240
      Euk_Ferritin; eukaryotic ferritins
      pfam00210
      Location:79 → 226
      Ferritin; Ferritin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI27 A0A0B4KI27
    B8A405 B8A405
    H1UUD2 H1UUD2
    Q7JMW3 Q7JMW3
    Q7KMQ5 Q7KMQ5
    Q7KRU8 Q7KRU8
    Q7KRU8.1
    Q8I0T0 Q8I0T0

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