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    Arxes2 adipocyte-related X-chromosome expressed sequence 2 [ Mus musculus (house mouse) ]

    Gene ID: 76976, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Arxes2provided by MGI
    Official Full Name
    adipocyte-related X-chromosome expressed sequence 2provided by MGI
    Primary source
    MGI:MGI:1924226
    See related
    Ensembl:ENSMUSG00000048040 AllianceGenome:MGI:1924226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spcs3; Spc22/23; 2900062L11Rik
    Summary
    Acts upstream of or within fat cell differentiation. Located in endoplasmic reticulum. Is expressed in axial musculature; eye; incisor; and nervous system. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Arxes2 in Genome Data Viewer
    Location:
    X F1; X 57.35 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134894569..134896108)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135993820..135995359)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor associated sorting protein 2 Neighboring gene basic helix-loop-helix domain containing, class B9 Neighboring gene STARR-seq mESC enhancer starr_47972 Neighboring gene predicted gene, 31214 Neighboring gene adipocyte-related X-chromosome expressed sequence 1 Neighboring gene predicted gene, 54084

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arxes: retrotransposed genes required for adipogenesis. Prokesch A, et al. Nucleic Acids Res, 2011 Apr. PMID 21177646, Free PMC Article
    2. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adipocyte-related X-chromosome expressed sequence 2
    Names
    SPase 22 kDa subunit
    SPase 22/23 kDa subunit
    microsomal signal peptidase 22/23 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029823.2 → NP_084099.1  adipocyte-related X-chromosome expressed sequence 2

      See identical proteins and their annotated locations for NP_084099.1

      Status: VALIDATED

      Source sequence(s)
      AA286632, AK077432, AV333270, BY773138
      Consensus CDS
      CCDS30411.1
      UniProtKB/Swiss-Prot
      B1AUR7, C0HK79, C0HK80, Q8BK31, Q9D365, Q9D6F2
      Related
      ENSMUSP00000051250.8, ENSMUST00000058119.9
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 173
      SPC22; Signal peptidase subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134894569..134896108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003642.1: Suppressed sequence

      Description
      NR_003642.1: This RefSeq was permanently suppressed because it is now thought that this gene encodes a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0HK80.1 GenPept UniProtKB/Swiss-Prot:C0HK80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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