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    CG11200 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37301, updated on 10-May-2024

    Summary

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    Official Symbol
    CG11200provided by FlyBase
    Primary source
    FLYBASE:FBgn0034500
    Locus tag
    Dmel_CG11200
    See related
    AllianceGenome:FB:FBgn0034500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11200
    Summary
    Predicted to enable NADP-retinol dehydrogenase activity. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval salivary gland common duct; extended germ band embryo; and presumptive embryonic/larval system. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG11200 in Genome Data Viewer
    Location:
    56F16-56F16; 2-90 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20304517..20308671, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16192022..16196176, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44640 Neighboring gene long non-coding RNA:CR44641 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44642 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Rival T, et al. Eur J Neurosci, 2009 Apr. PMID 19519625, Free PMC Article
    2. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article
    3. Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose. Ji Z, et al. Elife, 2021 Apr 13. PMID 33847264, Free PMC Article
    4. Modeling spinal muscular atrophy in Drosophila. Chang HC, et al. PLoS One, 2008 Sep 15. PMID 18791638, Free PMC Article
    5. Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC). Borrás T, et al. Genetics, 2003 Feb. PMID 12618402, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11200-PA
    CG11200-PB
    CG11200-PC
    carbonyl reductase
    NP_001286630.1
    NP_611471.1
    NP_725952.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      20304517..20308671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299701.1 → NP_001286630.1  uncharacterized protein Dmel_CG11200, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286630.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0F7
      Conserved Domains (2) summary
      PRK06196
      Location:56 → 344
      PRK06196; oxidoreductase; Provisional
      cl21454
      Location:67 → 338
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_137627.4 → NP_611471.1  uncharacterized protein Dmel_CG11200, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0F7
      Related
      FBpp0085611
      Conserved Domains (2) summary
      PRK06196
      Location:56 → 344
      PRK06196; oxidoreductase; Provisional
      cl21454
      Location:67 → 338
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_166388.3 → NP_725952.1  uncharacterized protein Dmel_CG11200, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0F7
      Related
      FBpp0085612
      Conserved Domains (2) summary
      PRK06196
      Location:56 → 344
      PRK06196; oxidoreductase; Provisional
      cl21454
      Location:67 → 338
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0F7 Q7K0F7

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