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    RNU5A-1 RNA, U5A small nuclear 1 [ Homo sapiens (human) ]

    Gene ID: 26831, updated on 10-Oct-2023

    Summary

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    Official Symbol
    RNU5A-1provided by HGNC
    Official Full Name
    RNA, U5A small nuclear 1provided by HGNC
    Primary source
    HGNC:HGNC:10211
    See related
    Ensembl:ENSG00000199568 MIM:180691; AllianceGenome:HGNC:10211
    Gene type
    snRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    U5A; RNU5; U5B1; RNU5A; RNU5C
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    Genomic context

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    Location:
    15q22.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65296051..65296167)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63105415..63105531)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65588389..65588505)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 686, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532106-65532606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65532607-65533107 Neighboring gene poly(ADP-ribose) polymerase family member 16 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:65545798-65546298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9594 Neighboring gene small nucleolar RNA, H/ACA box 24B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:65588516-65589427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65593529-65594044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6555 Neighboring gene RNA, U5B small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65618173-65618716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65624736-65625408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65626438-65627016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65627017-65627595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65628175-65628752 Neighboring gene immunoglobulin superfamily DCC subclass member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65647365-65647867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65647868-65648370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65648371-65648873 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65655395-65656260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65659717-65660580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65660581-65661444

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High evolutionary conservation of the secondary structure and of certain nucleotide sequences of U5 RNA. Branlant C, et al. Nucleic Acids Res, 1983 Dec 10. PMID 6200827, Free PMC Article
    2. The nuclear 5S RNAs from chicken, rat and man. U5 RNAs are encoded by multiple genes. Krol A, et al. Nucleic Acids Res, 1981 Feb 25. PMID 6164980, Free PMC Article
    3. Three novel functional variants of human U5 small nuclear RNA. Sontheimer EJ, et al. Mol Cell Biol, 1992 Feb. PMID 1310151, Free PMC Article
    4. The multifunctional human p100 protein 'hooks' methylated ligands. Shaw N, et al. Nat Struct Mol Biol, 2007 Aug. PMID 17632523
    5. Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3'-to-5' RNA exonuclease processing U6 small nuclear RNA. Shchepachev V, et al. Cell Rep, 2012 Oct 25. PMID 23022480

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Other Names

    • RNA, U5C small nuclear

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in formation of quadruple SL/U4/U5/U6 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal tri-snRNP complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002756.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068213
      Related
      ENST00000362698.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65296051..65296167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      63105415..63105531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases