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    hspa5.L heat shock protein family A (Hsp70) member 5 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397850, updated on 11-Apr-2024

    Summary

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    Official Symbol
    hspa5.L
    Official Full Name
    heat shock protein family A (Hsp70) member 5 L homeolog
    Primary source
    Xenbase:XB-GENE-17331987
    Locus tag
    XELAEV_180384511mg
    See related
    EnsemblRapid:ENSXLAG00005020149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    XAP-1; grp78; hspa5; hspa5a; BiP/Grp78
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    Genomic context

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    Location:
    chromosome: 8L
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (18373410..18382559)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8L NC_030738.1 (10652876..10671955)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene Rab9 effector protein with kelch motifs L homeolog Neighboring gene uncharacterized LOC121396887 Neighboring gene suppressor of cancer cell invasion L homeolog Neighboring gene GTPase activating protein and VPS9 domains 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degradation and endoplasmic reticulum retention of unassembled alpha- and beta-subunits of Na,K-ATPase correlate with interaction of BiP. Beggah A, et al. J Biol Chem, 1996 Aug 23. PMID 8702846
    2. An in vivo screen to identify candidate neurogenic genes in the developing Xenopus visual system. Bestman JE, et al. Dev Biol, 2015 Dec 15. PMID 25818835, Free PMC Article
    3. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within midbrain development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of IRE1-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of endoplasmic reticulum chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum chaperone BiP
    Names
    78 kDa glucose-regulated protein
    GRP-78
    HSP70 family protein 5
    biP
    binding-immunoglobulin protein
    heat shock 70 kDa protein 5
    heat shock 70 kDa protein 5a
    heat shock protein 70 family protein 5
    heat shock protein family A member 5
    heavy-chain binding protein BiP
    immunoglobulin binding protein
    immunoglobulin heavy chain-binding protein
    NP_001081462.1
    XP_018084185.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087993.1 → NP_001081462.1  endoplasmic reticulum chaperone BiP precursor

      See identical proteins and their annotated locations for NP_001081462.1

      Status: PROVISIONAL

      Source sequence(s)
      U62807
      UniProtKB/Swiss-Prot
      Q91883
      UniProtKB/TrEMBL
      Q6DD68
      Related
      ENSXLAP00005059022.1, ENSXLAT00005060462.1
      Conserved Domains (2) summary
      cd10241
      Location:30 → 404
      HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins
      pfam00012
      Location:32 → 636
      HSP70; Hsp70 protein

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      18373410..18382559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018228696.2 → XP_018084185.1  endoplasmic reticulum chaperone BiP isoform X1

      UniProtKB/TrEMBL
      A0A1L8F6I3, A0A974C5Z0, Q6DD68
      Related
      ENSXLAP00005059057.1, ENSXLAT00005060497.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91883.1 GenPept UniProtKB/Swiss-Prot:Q91883

    Gene LinkOut

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    Research Materials
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