Acad11 acyl-CoA dehydrogenase family, member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acad11provided by RGD
Official Full Name: acyl-CoA dehydrogenase family, member 11provided by RGD
Primary source: RGD:1306270
See related: Ensembl:ENSRNOG00000010940 AllianceGenome:RGD:1306270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306270
Summary: Predicted to enable medium-chain-acyl-CoA dehydrogenase activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in peroxisome. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 544.8), Kidney (RPKM 225.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (113560142..113625346)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (104681346..104746559)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (112594758..112676275)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A significant up-regulation of Cpt1a, Acadl and Sirt3, all beta-oxidation genes, along with a significant deacetylation of the forkhead transcription factor 3a (FOXO3A) was found in alpha-LA-treated animals.
Title: Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables very-long-chain fatty acyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl-CoA dehydrogenase family member 11

Names: ACAD-11; acyl-Coenzyme A dehydrogenase family, member 11

NP_001101651.1

EC 1.3.8.-

XP_038937486.1

EC 1.3.8.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108181.1 → NP_001101651.1 acyl-CoA dehydrogenase family member 11

See identical proteins and their annotated locations for NP_001101651.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/Swiss-Prot

B3DMA2

UniProtKB/TrEMBL

A0A8I5ZR07, A0A8I6AMR1

Related

ENSRNOP00000036574.4, ENSRNOT00000038383.6

Conserved Domains (3) summary

cd01155
Location:376 → 769

ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2

PLN02876
Location:10 → 769

PLN02876; acyl-CoA dehydrogenase

cd05154
Location:42 → 295

ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

113560142..113625346

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081558.2 → XP_038937486.1 acyl-CoA dehydrogenase family member 11 isoform X1

UniProtKB/TrEMBL

A0A8L2R5W9

Related

ENSRNOP00000072442.2

Conserved Domains (1) summary

PLN02876
Location:10 → 539

PLN02876; acyl-CoA dehydrogenase