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    SAC9 sacI homology domain-containing protein / WW domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825146, updated on 7-Sep-2023

    Summary

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    Gene symbol
    SAC9
    Gene description
    sacI homology domain-containing protein / WW domain-containing protein
    Primary source
    Araport:AT3G59770
    Locus tag
    AT3G59770
    See related
    TAIR:AT3G59770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SUPPRESSOR OF ACTIN 9; AtSAC9; SUPPRESSOR OF ACTIN 9
    Summary
    Encodes a phosphoinositide phosphatase. The sac9 null mutant accumulates elevated levels of PtdIns(4,5)P2 and Ins(1,4,5)P3. The mutant plants have characteristics of constitutive stress responses.
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    Genomic context

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    See SAC9 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (22078972..22086236, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene O-acetylserine (thiol) lyase isoform C Neighboring gene ncRNA Neighboring gene Rhodanese/Cell cycle control phosphatase superfamily protein Neighboring gene MAP kinase 10 Neighboring gene stress response protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique cell wall abnormalities in the putative phosphoinositide phosphatase mutant AtSAC9. Vollmer AH, et al. Planta, 2011 Nov. PMID 21698459
    2. Slow dark deactivation of Arabidopsis chloroplast ATP synthase caused by a mutation in a nonplastidic SAC domain protein. Gong P, et al. Photosynth Res, 2006 May. PMID 16453058
    3. Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway. Williams ME, et al. Plant Physiol, 2005 Jun. PMID 15923324, Free PMC Article
    4. Mutants of Arabidopsis thaliana with altered cell wall polysaccharide composition. Reiter WD, et al. Plant J, 1997 Aug. PMID 9301086
    5. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roots of sac9 mutants have abnormal cell walls and stunted growth.
      Title: Unique cell wall abnormalities in the putative phosphoinositide phosphatase mutant AtSAC9.
    2. These results suggest that the SAC9 phosphatase is involved in modulating phosphoinsitide signals during the stress response.
      Title: Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.
    3. This study demonstrated that SAC9 dysfunction interferes with ATP synthase deactivation, possibly by an alteration in phosphoinositide signaling inducing a stress mimicry response.
      Title: Slow dark deactivation of Arabidopsis chloroplast ATP synthase caused by a mutation in a nonplastidic SAC domain protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035819.1
    NM_001203209.1
    NM_001339998.1
    NM_115839.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to high light intensity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in intracellular anatomical structure TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sacI homology domain-containing protein / WW domain-containing protein
    NP_001030896.1
    • SUPPRESSOR OF ACTIN 9 (SAC9); FUNCTIONS IN: inositol or phosphatidylinositol phosphatase activity; INVOLVED IN: response to high light intensity, phosphatidylinositol metabolic process, response to cold, phosphoinositide-mediated signaling, response to osmotic stress; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WW/Rsp5/WWP (InterPro:IPR001202), Synaptojanin, N-terminal (InterPro:IPR002013); BEST Arabidopsis thaliana protein match is: Phosphoinositide phosphatase family protein (TAIR:AT1G17340.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001190138.1
    • SUPPRESSOR OF ACTIN 9 (SAC9); CONTAINS InterPro DOMAIN/s: WW/Rsp5/WWP (InterPro:IPR001202), Synaptojanin, N-terminal (InterPro:IPR002013); BEST Arabidopsis thaliana protein match is: Phosphoinositide phosphatase family protein (TAIR:AT1G17340.1).
    NP_191536.2
    • SUPPRESSOR OF ACTIN 9 (SAC9); FUNCTIONS IN: inositol or phosphatidylinositol phosphatase activity; INVOLVED IN: response to high light intensity, phosphatidylinositol metabolic process, response to cold, phosphoinositide-mediated signaling, response to osmotic stress; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: WW/Rsp5/WWP (InterPro:IPR001202), Synaptojanin, N-terminal (InterPro:IPR002013); BEST Arabidopsis thaliana protein match is: Phosphoinositide phosphatase family protein (TAIR:AT1G17340.1); Has 3998 Blast hits to 2752 proteins in 237 species: Archae - 0; Bacteria - 0; Metazoa - 2445; Fungi - 904; Plants - 298; Viruses - 0; Other Eukaryotes - 351 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22078972..22086236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115839.4 → NP_191536.2  sacI homology domain-containing protein / WW domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191536.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WUS3, Q7XZU0, Q9M1Z7
      UniProtKB/TrEMBL
      A0A5S9XMB9, A0A654FJB0
      Conserved Domains (2) summary
      smart00456
      Location:509 → 540
      WW; Domain with 2 conserved Trp (W) residues
      pfam02383
      Location:85 → 392
      Syja_N; SacI homology domain

    2. NM_001339998.1 → NP_001326481.1  sacI homology domain-containing protein / WW domain-containing protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPE6, A0A654FJB0

    3. NM_001203209.1 → NP_001190138.1  sacI homology domain-containing protein / WW domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XMB9, A0A654FJB0, F4J9G0
      Conserved Domains (2) summary
      smart00456
      Location:509 → 540
      WW; Domain with 2 conserved Trp (W) residues
      pfam02383
      Location:85 → 392
      Syja_N; SacI homology domain

    4. NM_001035819.1 → NP_001030896.1  sacI homology domain-containing protein / WW domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FJB0, F4J9G1
      Conserved Domains (3) summary
      smart00456
      Location:284 → 315
      WW; Domain with 2 conserved Trp (W) residues
      COG5329
      Location:2 → 431
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam02383
      Location:2 → 167
      Syja_N; SacI homology domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XZU0.1

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