Vcan versican [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vcanprovided by MGI
Official Full Name: versicanprovided by MGI
Primary source: MGI:MGI:102889
See related: Ensembl:ENSMUSG00000021614 AllianceGenome:MGI:102889
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NG2; hdf; PG-M; Cspg2; DPEAAE; PG-M(V0); PG-M(V1); 9430051N09; 5430420N07Rik
Summary: Enables protein phosphatase binding activity. Acts upstream of or within heart development and ureteric bud development. Located in extracellular matrix. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and jaw. Human ortholog(s) of this gene implicated in intracranial aneurysm. Orthologous to human VCAN (versican). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 25.2), CNS E11.5 (RPKM 14.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 45.5 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (89803429..89891146, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (89655309..89743027, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair.
Title: Versican Promotes Cardiomyocyte Proliferation and Cardiac Repair.
Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
Title: Versican accumulation drives Nos2 induction and aortic disease in Marfan syndrome via Akt activation.
The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors.
Title: The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors.
Versican contributes to ligament formation of knee joints.
Title: Versican contributes to ligament formation of knee joints.
The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation.
Title: The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation.
Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
Title: Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Title: Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation.
Title: Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Title: Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.
Title: Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (5) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237070

NoName (e-PCR)
- UniSTS:548435

NoName (e-PCR)
- UniSTS:548436

NoName (e-PCR)
- UniSTS:548437

NoName (e-PCR)
- UniSTS:548438

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141423

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141424

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141425

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141426

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141427

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141428

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141429

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141430

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141431

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141432

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141433

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141434

AA986891 (e-PCR)
- UniSTS:185978

Cspg2 (e-PCR), detects polymorphism
- UniSTS:141435

RH134008 (e-PCR)
- UniSTS:217290

Vcan (e-PCR), detects polymorphism
- UniSTS:265456

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in ureteric bud development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perineuronal net	IBA Inferred from Biological aspect of Ancestor more info
located_in perineuronal net	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: versican core protein

Names: PG-M core protein; chondroitin sulfate proteoglycan core protein 2; large fibroblast proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081249.1 → NP_001074718.1 versican core protein isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also referred to as V0).

Source sequence(s)

AC134397, AC154460

Consensus CDS

CCDS36740.1

UniProtKB/Swiss-Prot

Q62058, Q62059, Q9CUU0

UniProtKB/TrEMBL

E9PYH0

Related

ENSMUSP00000105173.3, ENSMUST00000109546.9

Conserved Domains (7) summary

cd05901
Location:36 → 151

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:3254 → 3310

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:3127 → 3250

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

smart00410
Location:29 → 147

IG_like; Immunoglobulin like

cd00054
Location:3085 → 3121

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 → 244

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 → 346

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
NM_001134474.1 → NP_001127946.1 versican core protein isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3, also referred to as V2), compared to isoform 1.

Source sequence(s)

AC134397, AC154460

Consensus CDS

CCDS49324.1

UniProtKB/TrEMBL

E9QMK2

Related

ENSMUSP00000105171.3, ENSMUST00000109544.9

Conserved Domains (7) summary

cd05901
Location:36 → 151

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:1515 → 1571

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:1388 → 1511

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

smart00410
Location:29 → 147

IG_like; Immunoglobulin like

cd00054
Location:1346 → 1382

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 → 244

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 → 346

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
NM_001134475.1 → NP_001127947.1 versican core protein isoform 4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 4, also referred to as V3), compared to isoform 1.

Source sequence(s)

AC134397, AC154460

Consensus CDS

CCDS49322.1

UniProtKB/TrEMBL

E9QMK3

Related

ENSMUSP00000105170.3, ENSMUST00000109543.9

Conserved Domains (7) summary

cd05901
Location:36 → 151

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:555 → 611

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00410
Location:29 → 147

IG_like; Immunoglobulin like

cd00054
Location:386 → 422

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 → 244

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 → 346

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cl02432
Location:428 → 551

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_019389.2 → NP_062262.2 versican core protein isoform 2 precursor

See identical proteins and their annotated locations for NP_062262.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2, also referred to as V1), compared to isoform 1.

Source sequence(s)

AC134397, AC154460

Consensus CDS

CCDS49323.1

UniProtKB/TrEMBL

G3XA35

Related

ENSMUSP00000125446.2, ENSMUST00000159910.8

Conserved Domains (7) summary

cd05901
Location:36 → 151

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:2294 → 2350

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:2167 → 2290

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

smart00410
Location:29 → 147

IG_like; Immunoglobulin like

cd00054
Location:2125 → 2161

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 → 244

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 → 346

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
NM_172955.1 → NP_766543.1 versican core protein isoform 5 precursor

See identical proteins and their annotated locations for NP_766543.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AC134397, AK034871

Consensus CDS

CCDS49321.1

UniProtKB/TrEMBL

Q4VA91, Q8BS97

Related

ENSMUSP00000125432.2, ENSMUST00000159337.8

Conserved Domains (4) summary

cd05901
Location:36 → 151

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

smart00410
Location:29 → 147

IG_like; Immunoglobulin like

cd03517
Location:150 → 244

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 → 346

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

89803429..89891146 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244471.4 → XP_011242773.2 versican core protein isoform X1

Conserved Domains (3) summary

cd00033
Location:1970 → 2026

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:1843 → 1966

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

cd00054
Location:1801 → 1837

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...