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    Baiap3 BAI1-associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 545192, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Baiap3provided by MGI
    Official Full Name
    BAI1-associated protein 3provided by MGI
    Primary source
    MGI:MGI:2685783
    See related
    Ensembl:ENSMUSG00000047507 AllianceGenome:MGI:2685783
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bap3; Gm937
    Summary
    Predicted to enable calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in regulation of GABAergic synaptic transmission and regulation of behavior. Located in GABA-ergic synapse. Is expressed in brain. Orthologous to human BAIAP3 (BAI1 associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 8.6), CNS E18 (RPKM 8.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25461633..25475255, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25242659..25256364, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene microRNA 3547 Neighboring gene ubiquitin-conjugating enzyme E2I Neighboring gene STARR-positive B cell enhancer ABC_E8659 Neighboring gene predicted gene, 17801 Neighboring gene serine protease 34

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. Wojcik SM, et al. Mol Med, 2013 Jul 24. PMID 23698091, Free PMC Article
    2. Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis. Man KN, et al. Elife, 2015 Nov 17. PMID 26575293, Free PMC Article
    3. Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. Vogl C, et al. J Cell Sci, 2015 Feb 15. PMID 25609709
    4. mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Dillman AA, et al. Nat Neurosci, 2013 Apr. PMID 23416452, Free PMC Article
    5. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis. Scavuzzo MA, et al. Nat Commun, 2018 Aug 22. PMID 30135482, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Baiap3 is gender specifically associated with anxiety and benzodiazepine use disorder.
      Title: Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dense core granule maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dense core granule exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dense core granule exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in secretory vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BAI1-associated protein 3
    Names
    brain-specific angiogenesis inhibitor I-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163270.2 → NP_001156742.1  BAI1-associated protein 3

      See identical proteins and their annotated locations for NP_001156742.1

      Status: VALIDATED

      Source sequence(s)
      AC122454
      Consensus CDS
      CCDS50033.1
      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7
      UniProtKB/TrEMBL
      B2RY68
      Related
      ENSMUSP00000138188.2, ENSMUST00000182056.8
      Conserved Domains (3) summary
      cd04009
      Location:973 → 1102
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:131 → 330
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:852 → 954
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain

    2. NM_001408206.1 → NP_001395135.1  BAI1-associated protein 3

      Status: VALIDATED

      Source sequence(s)
      AC122454
      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25461633..25475255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524643.5 → XP_006524706.1  BAI1-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006524706.1

      UniProtKB/Swiss-Prot
      E9QQ76, Q6RUT4, Q80TT2, S4R1E7
      UniProtKB/TrEMBL
      B2RY68
      Conserved Domains (3) summary
      cd04009
      Location:973 → 1102
      C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins
      cd08676
      Location:131 → 330
      C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins
      pfam10540
      Location:852 → 954
      Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TT2.4 GenPept UniProtKB/Swiss-Prot:Q80TT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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