U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hpca hippocalcin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29177, updated on 30-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hpcaprovided by RGD
    Official Full Name
    hippocalcinprovided by RGD
    Primary source
    RGD:620060
    See related
    Ensembl:ENSRNOG00000006979 AllianceGenome:RGD:620060
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity and kinase binding activity. Involved in several processes, including activation of phospholipase D activity; cellular response to electrical stimulus; and negative regulation of guanylate cyclase activity. Located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Is extrinsic component of membrane. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 582.6) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146739978..146750961, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141455616..141466252, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147295124..147305757, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 7-like Neighboring gene adenylate kinase 2 Neighboring gene uncharacterized LOC102551249 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene fibronectin type III domain containing 5 Neighboring gene S100P binding protein Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Perturbed Ca(2+)-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia. Osypenko DS, et al. Neurobiol Dis, 2019 Dec. PMID 31301343
    2. Diabetes aggravates decreases in hippocalcin and parvalbumin expression in focal cerebral ischemia. Park DJ, et al. Neurosci Lett, 2018 Jan 1. PMID 29061397
    3. Expression profiling shows differential molecular pathways and provides potential new diagnostic biomarkers for colorectal serrated adenocarcinoma. Conesa-Zamora P, et al. Int J Cancer, 2013 Jan 15. PMID 22696308
    4. Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Jo J, et al. Nat Neurosci, 2010 Oct. PMID 20852624
    5. Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons. Dovgan AV, et al. Eur J Neurosci, 2010 Aug. PMID 20704590, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slow after hyperpolarization was identified as a downstream cellular target perturbed by a hippocalin mutation in DYT2 dystonia.
      Title: Perturbed Ca(2+)-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia.
    2. Study results suggest that significantly decreased levels of hippocalcin and parvalbumin exacerbate neuronal cell death in diabetic animals with ischemic brain injury.
      Title: Diabetes aggravates decreases in hippocalcin and parvalbumin expression in focal cerebral ischemia.
    3. These results indicate that Hpca associates with BB-CK and that together they translocate to membrane compartments in a Ca(2+)-dependent manner.
      Title: Hippocalcin mediates calcium-dependent translocation of brain-type creatine kinase (BB-CK) in hippocampal neurons.
    4. Suggest that the maintenance of parvalbumin and hippocalcin levels by melatonin in ischemic injury contributes to the neuroprotective effect of melatonin against neuronal cell damage.
      Title: Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury.
    5. hippocalcin may differentially decode patterns of glutamate receptor activation into site- and time-specific translocation to its targets. Hippocalcin can also produce local signaling at synapses providing a molecular mechanism for homosynaptic plasticity
      Title: Decoding glutamate receptor activation by the Ca2+ sensor protein hippocalcin in rat hippocampal neurons.
    6. Exhibits similar patterns of regulation during development and epileptogenesis
      Title: Overlapping microarray profiles of dentate gyrus gene expression during development- and epilepsy-associated neurogenesis and axon outgrowth.
    7. Taken together, these results suggest for the first time that hippocalcin can induce PLD2 expression and LPA potentiates hippocalcin-induced PLD2 expression, which is mediated by ERK activation.
      Title: Hippocalcin increases phospholipase D2 expression through extracellular signal-regulated kinase activation and lysophosphatidic acid potentiates the hippocalcin-induced phospholipase D2 expression.
    8. These data indicate that the AP2-hippocalcin complex acts as a Ca(2+) sensor that couples NMDAR-dependent activation to regulated endocytosis of AMPARs during LTD.
      Title: Hippocalcin functions as a calcium sensor in hippocampal LTD.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC105450

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to L-glutamate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to Aroclor 1254 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to L-glutamate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to ketamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in retina development in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendritic spine head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    neuron-specific calcium-binding protein hippocalcin
    Names
    P23K
    calcium-binding protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017122.2 → NP_058818.1  neuron-specific calcium-binding protein hippocalcin

      See identical proteins and their annotated locations for NP_058818.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P84076
      Related
      ENSRNOP00000009153.5, ENSRNOT00000009153.8
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      146739978..146750961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238920.4 → XP_006238982.1  neuron-specific calcium-binding protein hippocalcin isoform X1

      See identical proteins and their annotated locations for XP_006238982.1

      UniProtKB/Swiss-Prot
      P84076
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    2. XM_006238921.5 → XP_006238983.1  neuron-specific calcium-binding protein hippocalcin isoform X1

      See identical proteins and their annotated locations for XP_006238983.1

      UniProtKB/Swiss-Prot
      P84076
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84076.2 GenPept UniProtKB/Swiss-Prot:P84076

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous