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    Xpot exportin, tRNA (nuclear export receptor for tRNAs) [ Mus musculus (house mouse) ]

    Gene ID: 73192, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Xpotprovided by MGI
    Official Full Name
    exportin, tRNA (nuclear export receptor for tRNAs)provided by MGI
    Primary source
    MGI:MGI:1920442
    See related
    Ensembl:ENSMUSG00000034667 AllianceGenome:MGI:1920442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EXPORTIN-T; 1110004L07Rik; 3110065H13Rik
    Summary
    Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in endocrine gland; female reproductive system; mammary gland; peripheral nervous system; and trigeminal nerve. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.2), liver E14 (RPKM 10.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xpot in Genome Data Viewer
    Location:
    10 D2; 10 69.86 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121423285..121462411, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121587380..121626506, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35696 Neighboring gene TANK-binding kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1129 Neighboring gene STARR-positive B cell enhancer ABC_E9355 Neighboring gene STARR-seq mESC enhancer starr_28102 Neighboring gene predicted gene, 35816 Neighboring gene RIKEN cDNA D930020B18 gene Neighboring gene STARR-seq mESC enhancer starr_28105 Neighboring gene predicted gene, 35865

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article
    2. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
    3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA re-export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exportin-T
    Names
    exportin(tRNA)
    tRNA exportin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081056.3 → NP_001074525.1  exportin-T isoform 1

      See identical proteins and their annotated locations for NP_001074525.1

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      Consensus CDS
      CCDS88093.1
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      UniProtKB/TrEMBL
      A0A1W2P7Q6
      Related
      ENSMUSP00000151722.2, ENSMUST00000218004.2
      Conserved Domains (2) summary
      smart00913
      Location:21 → 88
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100 → 247
      Xpo1; Exportin 1-like protein

    2. NM_001359618.2 → NP_001346547.1  exportin-T isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992
      Consensus CDS
      CCDS88093.1
      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      UniProtKB/TrEMBL
      A0A1W2P7Q6
      Conserved Domains (2) summary
      smart00913
      Location:21 → 88
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100 → 247
      Xpo1; Exportin 1-like protein

    3. NM_001401044.1 → NP_001387973.1  exportin-T isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992

    4. NM_001401045.1 → NP_001387974.1  exportin-T isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124413, AC124992

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      121423285..121462411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245308.1 → XP_030101168.1  exportin-T isoform X3

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (1) summary
      pfam08389
      Location:6 → 137
      Xpo1; Exportin 1-like protein

    2. XM_006514208.5 → XP_006514271.1  exportin-T isoform X3

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (1) summary
      pfam08389
      Location:6 → 137
      Xpo1; Exportin 1-like protein

    3. XM_030245306.2 → XP_030101166.1  exportin-T isoform X1

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:21 → 88
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98 → 245
      Xpo1; Exportin 1-like protein

    4. XM_006514206.4 → XP_006514269.1  exportin-T isoform X1

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:21 → 88
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:98 → 245
      Xpo1; Exportin 1-like protein

    5. XM_006514207.5 → XP_006514270.1  exportin-T isoform X2

      UniProtKB/Swiss-Prot
      Q52KI1, Q9CRT8
      Conserved Domains (2) summary
      smart00913
      Location:21 → 88
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:100 → 247
      Xpo1; Exportin 1-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRT8.3 GenPept UniProtKB/Swiss-Prot:Q9CRT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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