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    Lrp3 low density lipoprotein receptor-related protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 435965, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Lrp3provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein 3provided by MGI
    Primary source
    MGI:MGI:3584516
    See related
    Ensembl:ENSMUSG00000001802 AllianceGenome:MGI:3584516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; and regulation of gene expression. Predicted to be active in plasma membrane. Orthologous to human LRP3 (LDL receptor related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in whole brain E14.5 (RPKM 26.3), CNS E14 (RPKM 25.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B2; 7 21.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (34900303..34914770, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35200878..35217392, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35889 Neighboring gene predicted gene, 38988 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 10 Neighboring gene predicted gene, 24505 Neighboring gene predicted gene, 38989 Neighboring gene nuclear encoded tRNA threonine 9 (anticodon AGT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4. Cao C, et al. Nat Commun, 2022 Nov 21. PMID 36414669, Free PMC Article
    2. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Spoelgen R, et al. Neuroscience, 2009 Feb 18. PMID 19047013, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4.
      Title: Cholesterol-induced LRP3 downregulation promotes cartilage degeneration in osteoarthritis by targeting Syndecan-4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024707.2 → NP_001019878.1  low-density lipoprotein receptor-related protein 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK149314, BC094349, CJ106421
      Consensus CDS
      CCDS52202.1
      UniProtKB/TrEMBL
      E9Q1T6, Q3UEV4
      Related
      ENSMUSP00000114026.2, ENSMUST00000122409.8
      Conserved Domains (2) summary
      cd00041
      Location:64 → 177
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00112
      Location:187 → 221
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. NM_001421534.1 → NP_001408463.1  low-density lipoprotein receptor-related protein 3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC150683
      UniProtKB/TrEMBL
      E9Q711

    RNA

    1. NR_185310.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC150683

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      34900303..34914770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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